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UCP3 Antikörper (N-Term)

This anti-UCP3 antibody (ABIN7603247) is a Rabbit Polyclonal antibody detecting UCP3 in WB. Suitable for Human, Mouse, Rat.
Produktnummer ABIN7603247

Kurzübersicht für UCP3 Antikörper (N-Term) (ABIN7603247)

Target

Alle UCP3 Antikörper anzeigen
UCP3 (Uncoupling Protein 3 (Mitochondrial, Proton Carrier) (UCP3))

Reaktivität

  • 38
  • 24
  • 15
  • 1
  • 1
Human, Maus, Ratte

Wirt

  • 39
  • 1
  • 1
Kaninchen

Klonalität

  • 40
  • 1
Polyklonal

Konjugat

  • 23
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
Dieser UCP3 Antikörper ist unkonjugiert

Applikation

  • 20
  • 15
  • 8
  • 3
  • 2
  • 2
Western Blotting (WB)
  • Bindungsspezifität

    • 6
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term

    Verwendungszweck

    Anti-UCP3 Antibody Picoband®

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins.

    Produktmerkmale

    Anti-UCP3 Antibody Picoband® (ABIN7603247). Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    A synthetic peptide corresponding to a sequence at the N-terminus of human UCP3, which shares 73.1% and 76.9% amino acid (aa) sequence identity with mouse and rat UCP3, respectively.

    Isotyp

    IgG
  • Applikationshinweise

    Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
    1. Argyropoulos, G., Brown, A. M., Willi, S. M., Zhu, J., He, Y., Reitman, M., Gevao, S. M., Spruill, I., Garvey, W. T. Effects of mutations in the human uncoupling protein 3 gene on the respiratory quotient and fat oxidation in severe obesity and type 2 diabetes. J. Clin. Invest. 102: 1345-1351, 1998. 2. Boss, O., Giacobino, J.-P., Muzzin, P. Genomic structure of uncoupling protein-3 (UCP3) and its assignment to chromosome 11q13. Genomics 47: 425-426, 1998. 3. Boss, O., Samec, S., Paoloni-Giacobino, A., Rossier, C., Dulloo, A., Seydoux, J., Muzzin, P., Giacobino, J.-P. Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression. FEBS Lett. 408: 39-42, 1997.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
  • Target

    UCP3 (Uncoupling Protein 3 (Mitochondrial, Proton Carrier) (UCP3))

    Andere Bezeichnung

    UCP3

    Hintergrund

    Synonyms: Ubiquitin-like-conjugating enzyme ATG3,6.3.2.-,Autophagy-related protein 3,APG3-like,hApg3,Protein PC3-96,ATG3,APG3, APG3L,

    Tissue Specificity: Widely expressed, with a highest expression in heart, skeletal muscle, kidney, liver and placenta. .

    Background: Mitochondrial uncoupling protein 3 is a protein that in humans is encoded by the UCP3 gene. Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. The different UCPs have tissue-specific expression, this gene is primarily expressed in skeletal muscle. This gene's protein product is postulated to protect mitochondria against lipid-induced oxidative stress. Expression levels of this gene increase when fatty acid supplies to mitochondria exceed their oxidation capacity and the protein enables the export of fatty acids from mitochondria. UCPs contain the three solcar protein domains typically found in MACPs. Two splice variants have been found for this gene.

    Molekulargewicht

    30 kDa

    Gen-ID

    7352

    UniProt

    P55916

    Pathways

    Proton Transport
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