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NAPB Antikörper (N-Term)

NAPB Reaktivität: Maus, Ratte WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7603230
  • Target Alle NAPB Antikörper anzeigen
    NAPB (N-Ethylmaleimide Sensitive Fusion Protein Attachment Protein beta (NAPB))
    Bindungsspezifität
    • 9
    • 6
    • 1
    • 1
    N-Term
    Reaktivität
    • 16
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Maus, Ratte
    Wirt
    • 16
    Kaninchen
    Klonalität
    • 16
    Polyklonal
    Konjugat
    • 11
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser NAPB Antikörper ist unkonjugiert
    Applikation
    • 16
    • 9
    • 2
    • 2
    • 1
    Western Blotting (WB)
    Verwendungszweck
    Anti-NAPB Antibody Picoband®
    Kreuzreaktivität (Details)
    No cross-reactivity with other proteins.
    Produktmerkmale
    Anti-NAPB Antibody Picoband® (ABIN7603230). Tested in WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
    Aufreinigung
    Immunogen affinity purified.
    Immunogen
    A synthetic peptide corresponding to a sequence at the N-terminusof human NAPB, identical to the related mouse and rat sequences.
    Isotyp
    IgG
    Top Product
    Discover our top product NAPB Primärantikörper
  • Applikationshinweise
    Western blot, 0.25-0.5 μg/mL, Mouse, Rat
    1. Burgalossi, A., Jung, S., Meyer, G., Jockusch, W. J., Jahn, O., Taschenberger, H., O'Connor, V. M., Nishiki, T., Takahashi, M., Brose, N., Rhee, J.-S. SNARE protein recycling by alpha-SNAP and beta-SNAP supports synaptic vesicle priming. Neuron 68: 473-487, 2010. Note: Erratum: Neuron 73: 620 only, 2012. 2. Conroy, J., Allen, N. M., Gorman, K. M., Shahwan, A., Ennis, S., Lynch, S. A., King, M. D. NAPB--a novel SNARE-associated protein for early-onset epileptic encephalopathy. Clin. Genet. 89: E1-E3, 2016. 3. Reuter, M. S., Tawamie, H., Buchert, R., Hosny Gebril, O., Froukh, T., Thiel, C., Uebe, S., Ekici, A. B., Krumbiegel, M., Zweier, C., Hoyer, J., Eberlein, K., and 17 others. Diagnostic yield and novel candidate genes by exome sequencing in 152 consanguineous families with neurodevelopmental disorders. JAMA Psychiat. 74: 293-299, 2017.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Konzentration
    500 μg/mL
    Buffer
    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
  • Target
    NAPB (N-Ethylmaleimide Sensitive Fusion Protein Attachment Protein beta (NAPB))
    Andere Bezeichnung
    NAPB (NAPB Produkte)
    Hintergrund

    Synonyms: Tafazzin, Protein G4.5, TAZ, EFE2, G4.5

    Tissue Specificity: High levels in cardiac and skeletal muscle. Up to 10 isoforms can be present in different amounts in different tissues. Most isoforms are ubiquitous. Isoforms that lack the N-terminus are found in leukocytes and fibroblasts, but not in heart and skeletal muscle. Some forms appear restricted to cardiac and skeletal muscle or to leukocytes.

    Background: Beta-soluble NSF attachment protein is a SNAP protein involved in vesicular trafficking and exocytosis which is encoded by the NAPB gene humans is. This gene encodes a member of the soluble N-ethyl-maleimide-sensitive fusion attachment protein (SNAP) family. SNAP proteins play a critical role in the docking and fusion of vesicles to target membranes as part of the 20S NSF-SNAP-SNARE complex. This gene encodes the SNAP beta isoform which has been shown to be preferentially expressed in brain tissue. The encoded protein also interacts with the GluR2 -amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor subunit C-terminus and may play a role as a chaperone in the molecular processing of the AMPA receptor.

    Molekulargewicht
    35 kDa
    Gen-ID
    63908
    UniProt
    Q9H115
    Pathways
    Synaptic Vesicle Exocytosis
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