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NAPB Antikörper (N-Term)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch NAPB in WB. Er zeigt eine Reaktivität gegenüber Maus und Ratte.
Produktnummer ABIN7603230

Kurzübersicht für NAPB Antikörper (N-Term) (ABIN7603230)

Target

Alle NAPB Antikörper anzeigen
NAPB (N-Ethylmaleimide Sensitive Fusion Protein Attachment Protein beta (NAPB))

Reaktivität

  • 16
  • 5
  • 5
  • 3
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Maus, Ratte

Wirt

  • 16
Kaninchen

Klonalität

  • 16
Polyklonal

Konjugat

  • 11
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser NAPB Antikörper ist unkonjugiert

Applikation

  • 16
  • 9
  • 2
  • 2
  • 1
Western Blotting (WB)
  • Bindungsspezifität

    • 9
    • 6
    • 1
    • 1
    N-Term

    Verwendungszweck

    Anti-NAPB Antibody Picoband®

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins.

    Produktmerkmale

    Anti-NAPB Antibody Picoband® (ABIN7603230). Tested in WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    A synthetic peptide corresponding to a sequence at the N-terminusof human NAPB, identical to the related mouse and rat sequences.

    Isotyp

    IgG
  • Applikationshinweise

    Western blot, 0.25-0.5 μg/mL, Mouse, Rat
    1. Burgalossi, A., Jung, S., Meyer, G., Jockusch, W. J., Jahn, O., Taschenberger, H., O'Connor, V. M., Nishiki, T., Takahashi, M., Brose, N., Rhee, J.-S. SNARE protein recycling by alpha-SNAP and beta-SNAP supports synaptic vesicle priming. Neuron 68: 473-487, 2010. Note: Erratum: Neuron 73: 620 only, 2012. 2. Conroy, J., Allen, N. M., Gorman, K. M., Shahwan, A., Ennis, S., Lynch, S. A., King, M. D. NAPB--a novel SNARE-associated protein for early-onset epileptic encephalopathy. Clin. Genet. 89: E1-E3, 2016. 3. Reuter, M. S., Tawamie, H., Buchert, R., Hosny Gebril, O., Froukh, T., Thiel, C., Uebe, S., Ekici, A. B., Krumbiegel, M., Zweier, C., Hoyer, J., Eberlein, K., and 17 others. Diagnostic yield and novel candidate genes by exome sequencing in 152 consanguineous families with neurodevelopmental disorders. JAMA Psychiat. 74: 293-299, 2017.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
  • Target

    NAPB (N-Ethylmaleimide Sensitive Fusion Protein Attachment Protein beta (NAPB))

    Andere Bezeichnung

    NAPB

    Hintergrund

    Synonyms: Tafazzin, Protein G4.5, TAZ, EFE2, G4.5

    Tissue Specificity: High levels in cardiac and skeletal muscle. Up to 10 isoforms can be present in different amounts in different tissues. Most isoforms are ubiquitous. Isoforms that lack the N-terminus are found in leukocytes and fibroblasts, but not in heart and skeletal muscle. Some forms appear restricted to cardiac and skeletal muscle or to leukocytes.

    Background: Beta-soluble NSF attachment protein is a SNAP protein involved in vesicular trafficking and exocytosis which is encoded by the NAPB gene humans is. This gene encodes a member of the soluble N-ethyl-maleimide-sensitive fusion attachment protein (SNAP) family. SNAP proteins play a critical role in the docking and fusion of vesicles to target membranes as part of the 20S NSF-SNAP-SNARE complex. This gene encodes the SNAP beta isoform which has been shown to be preferentially expressed in brain tissue. The encoded protein also interacts with the GluR2 -amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor subunit C-terminus and may play a role as a chaperone in the molecular processing of the AMPA receptor.

    Molekulargewicht

    35 kDa

    Gen-ID

    63908

    UniProt

    Q9H115

    Pathways

    Synaptic Vesicle Exocytosis
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