Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

GRID2 Antikörper (N-Term)

GRID2 Reaktivität: Human, Ratte, Maus WB, IHC, FACS Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7603172
  • Target Alle GRID2 Antikörper anzeigen
    GRID2 (Glutamate Receptor, Ionotropic, delta 2 (GRID2))
    Bindungsspezifität
    • 4
    • 2
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 14
    • 12
    • 11
    • 2
    Human, Ratte, Maus
    Wirt
    • 13
    • 2
    Kaninchen
    Klonalität
    • 14
    • 1
    Polyklonal
    Konjugat
    • 8
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser GRID2 Antikörper ist unkonjugiert
    Applikation
    • 8
    • 6
    • 4
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)
    Verwendungszweck
    Anti-GRID2 Antibody Picoband®
    Kreuzreaktivität (Details)
    No cross-reactivity with other proteins.
    Produktmerkmale
    Anti-GRID2 Antibody Picoband® (ABIN7603172). Tested in Flow Cytometry, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
    Aufreinigung
    Immunogen affinity purified.
    Immunogen
    A synthetic peptide corresponding to a sequence at the N-terminus of human GRID2, identical to the related mouse and rat sequences.
    Isotyp
    IgG
    Top Product
    Discover our top product GRID2 Primärantikörper
  • Applikationshinweise
    Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
    Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Human
    Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human, Rat
    1. Araki, K., Meguro, H., Kushiya, E., Takayama, C., Inoue, Y., Mishina, M. Selective expression of the glutamate receptor channel delta-2 subunit in cerebellar Purkinje cells. Biochem. Biophys. Res. Commun. 197: 1267-1276, 1993. 2. Hills, L. B., Masri, A., Konno, K., Kakegawa, W., Lam, A.-T. N., Lim-Melia, E., Chandy, N., Hill, R. S., Partlow, J. N., Al-Saffar, M., Nasir, R., Stoler, J. M., Barkovich, A. J., Watanabe, M., Yuzaki, M., Mochida, G. H. Deletions in GRID2 lead to a recessive syndrome of cerebellar ataxia and tonic upgaze in humans. Neurology 81: 1378-1386, 2013. 3. Hirai, H., Launey, T., Mikawa, S., Torashima, T., Yanagihara, D., Kasaura, T., Miyamoto, A., Yuzaki, M. New role of delta-2-glutamate receptors in AMPA receptor trafficking and cerebellar function. Nature Neurosci. 6: 869-876, 2003.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Konzentration
    500 μg/mL
    Buffer
    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.01 mg Sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Target
    GRID2 (Glutamate Receptor, Ionotropic, delta 2 (GRID2))
    Andere Bezeichnung
    GRID2 (GRID2 Produkte)
    Hintergrund

    Synonyms: Loricrin, LOR, LRN

    Tissue Specificity: Expressed in testis and to a lesser degree in brain, ovary and placenta. Found in most tissues at low levels.

    Background: Glutamate receptor, ionotropic, delta 2, also known as GluD2, GluRδ2, or δ2, is a protein that in humans is encoded by the GRID2 gene. The protein encoded by this gene is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause cerebellar ataxia in humans.

    Molekulargewicht
    113 kDa
    Gen-ID
    2895
    UniProt
    O43424
    Pathways
    Synaptic Membrane
Sie sind hier:
Chat with us!