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GRID2 Antikörper (N-Term)

Dieses Anti-GRID2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von GRID2 in WB, IHC und FACS. Geeignet für Human, Ratte und Maus.
Produktnummer ABIN7603172

Kurzübersicht für GRID2 Antikörper (N-Term) (ABIN7603172)

Target

Alle GRID2 Antikörper anzeigen
GRID2 (Glutamate Receptor, Ionotropic, delta 2 (GRID2))

Reaktivität

  • 15
  • 13
  • 12
  • 2
Human, Ratte, Maus

Wirt

  • 14
  • 2
Kaninchen

Klonalität

  • 15
  • 1
Polyklonal

Konjugat

  • 9
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser GRID2 Antikörper ist unkonjugiert

Applikation

  • 9
  • 7
  • 5
  • 2
  • 2
  • 2
  • 1
Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)
  • Bindungsspezifität

    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    N-Term

    Verwendungszweck

    Anti-GRID2 Antibody Picoband®

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins.

    Produktmerkmale

    Anti-GRID2 Antibody Picoband® (ABIN7603172). Tested in Flow Cytometry, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    A synthetic peptide corresponding to a sequence at the N-terminus of human GRID2, identical to the related mouse and rat sequences.

    Isotyp

    IgG
  • Applikationshinweise

    Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
    Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Human
    Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human, Rat
    1. Araki, K., Meguro, H., Kushiya, E., Takayama, C., Inoue, Y., Mishina, M. Selective expression of the glutamate receptor channel delta-2 subunit in cerebellar Purkinje cells. Biochem. Biophys. Res. Commun. 197: 1267-1276, 1993. 2. Hills, L. B., Masri, A., Konno, K., Kakegawa, W., Lam, A.-T. N., Lim-Melia, E., Chandy, N., Hill, R. S., Partlow, J. N., Al-Saffar, M., Nasir, R., Stoler, J. M., Barkovich, A. J., Watanabe, M., Yuzaki, M., Mochida, G. H. Deletions in GRID2 lead to a recessive syndrome of cerebellar ataxia and tonic upgaze in humans. Neurology 81: 1378-1386, 2013. 3. Hirai, H., Launey, T., Mikawa, S., Torashima, T., Yanagihara, D., Kasaura, T., Miyamoto, A., Yuzaki, M. New role of delta-2-glutamate receptors in AMPA receptor trafficking and cerebellar function. Nature Neurosci. 6: 869-876, 2003.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.01 mg Sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Target

    GRID2 (Glutamate Receptor, Ionotropic, delta 2 (GRID2))

    Andere Bezeichnung

    GRID2

    Hintergrund

    Synonyms: Loricrin, LOR, LRN

    Tissue Specificity: Expressed in testis and to a lesser degree in brain, ovary and placenta. Found in most tissues at low levels.

    Background: Glutamate receptor, ionotropic, delta 2, also known as GluD2, GluRδ2, or δ2, is a protein that in humans is encoded by the GRID2 gene. The protein encoded by this gene is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause cerebellar ataxia in humans.

    Molekulargewicht

    113 kDa

    Gen-ID

    2895

    UniProt

    O43424

    Pathways

    Synaptic Membrane
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