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UGT1A10 Antikörper (Middle Region)

Dieses Anti-UGT1A10-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von UGT1A10 in WB und FACS. Geeignet für Human.
Produktnummer ABIN7603103

Kurzübersicht für UGT1A10 Antikörper (Middle Region) (ABIN7603103)

Target

Alle UGT1A10 Antikörper anzeigen
UGT1A10 (UDP Glucuronosyltransferase 1 Family, Polypeptide A10 (UGT1A10))

Reaktivität

  • 12
  • 8
Human

Wirt

  • 9
  • 3
Kaninchen

Klonalität

  • 10
  • 2
Polyklonal

Konjugat

  • 5
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser UGT1A10 Antikörper ist unkonjugiert

Applikation

Western Blotting (WB), Flow Cytometry (FACS)
  • Bindungsspezifität

    • 2
    • 1
    • 1
    Middle Region

    Verwendungszweck

    Anti-UGT1A10 Antibody Picoband®

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins.

    Produktmerkmale

    Anti-UGT1A10 Antibody Picoband® (ABIN7603103). Tested in , Flow Cytometry, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    A synthetic peptide corresponding to a sequence in the middle region of human UGT1A10.

    Isotyp

    IgG
  • Applikationshinweise

    Western blot, 0.25-0.5 μg/mL, Human
    Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
    1. Basu, N. K., Ciotti, M., Hwang, M. S., Kole, L., Mitra, P. S., Cho, J. W., Owens, I. S. Differential and special properties of the major human UGT1-encoded gastrointestinal UDP-glucuronosyltransferases enhance potential to control chemical uptake. J. Biol. Chem. 279: 1429-1441, 2004. 2. Gong, Q.-H., Cho, J. W., Huang, T., Potter, C., Gholami, N., Basu, N. K., Kubota, S., Carvalho, S., Pennington, M. W., Owens, I. S., Popescu, N. C. Thirteen UDP-glucuronosyltransferase genes are encoded at the human UGT1 gene complex locus. Pharmacogenetics 11: 357-368, 2001. 3. Mackenzie, P. I., Bock, K. W., Burchell, B., Guillemette, C., Ikushiro, S., Iyanagi, T., Miners, J. O., Owens, I. S., Nebert, D. W. Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily. Pharmacogenet. Genomics 15: 677-685, 2005.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
  • Target

    UGT1A10 (UDP Glucuronosyltransferase 1 Family, Polypeptide A10 (UGT1A10))

    Andere Bezeichnung

    UGT1A10

    Hintergrund

    Synonyms: E3 ubiquitin-protein ligase RNF31, HOIL-1-interacting protein, HOIP, RING finger protein 31, RING-type E3 ubiquitin transferase RNF31, Zinc in-between-RING-finger ubiquitin-associated domain protein, RNF31, ZIBRA

    Tissue Specificity: Expressed in both normal and transformed breast epithelial cell lines.

    Background: UDP-glucuronosyltransferase 1-10 is an enzyme that in humans is encoded by the UGT1A10 gene. This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity on mycophenolic acid, coumarins, and quinolines.

    Molekulargewicht

    60 kDa

    Gen-ID

    54575

    Pathways

    Steroid Hormone Biosynthesis, Regulation of Lipid Metabolism by PPARalpha
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