GZMK Antikörper (Middle Region)

Produktnummer ABIN7603055

Dieses Anti-GZMK-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von GZMK in IHC. Geeignet für Human.

Kurzübersicht für GZMK Antikörper (Middle Region) (ABIN7603055)

Target: GZMK (Granzyme K (Granzyme 3, Tryptase II) (GZMK))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GZMK Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Produktdetails anti-GZMK Antikörper

Bindungsspezifität: Middle Region

Verwendungszweck: Anti-Granzyme K/GZMK Antibody

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-Granzyme K/GZMK Antibody Picoband® (ABIN7603055). Tested in IHC applications. This antibody reacts with Human.

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human Granzyme K/GZMK, which shares 71.4% and 73.9% amino acid (aa) sequence identity with mouse and rat GZMK, respectively.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human
1. Baker, E., Sayers, T. J., Sutherland, G. R., Smyth, M. J. The genes encoding NK cell granule serine proteases, human tryptase-2 (TRYP2) and human granzyme A (HFSP), both map to chromosome 5q11-q12 and define a new locus for cytotoxic lymphocyte granule tryptases. Immunogenetics 40: 235-237, 1994. 2. Przetak, M. M., Yoast, S., Schmidt, B. F. Cloning of cDNA for human granzyme 3. FEBS Lett. 364: 268-271, 1995. 3. Sayers, T. J., Lloyd, A. R., McVicar, D. W., O'Connor, M. D., Kelly, J. M., Carter, C. R. D., Wiltrout, T. A., Wiltrout, R. H., Smyth, M. J. Cloning and expression of a second human natural killer cell granule tryptase, HNK-Tryp-2/granzyme 3. J. Leuko. Biol. 59: 763-768, 1996.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Details zu GZMK

Target: GZMK (Granzyme K (Granzyme 3, Tryptase II) (GZMK))

Andere Bezeichnung: GZMK

Hintergrund:

Synonyms: ELAV-like protein 2, ELAV-like neuronal protein 1, Hu-antigen B, HuB, Nervous system-specific RNA-binding protein Hel-N1, ELAVL2, HUB

Tissue Specificity: Brain, neural-specific.

Background: Granzyme K is a protein that in humans is encoded by the GZMK gene. This gene product is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here lacks consensus sequences for N-glycosylation present in other granzymes

Molekulargewicht: 41 kDa

Gen-ID: 3003

UniProt: P49863