MC4R Antikörper (C-Term)

Produktnummer ABIN7602763

Der Kaninchen Polyklonal Anti-MC4R-Antikörper wurde für WB, IHC, IF, ICC und FACS validiert. Er ist geeignet, MC4R in Proben von Human, Ratte und Maus zu detektieren.

Kurzübersicht für MC4R Antikörper (C-Term) (ABIN7602763)

Target: MC4R (Melanocortin 4 Receptor (MC4R))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MC4R Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Produktdetails anti-MC4R Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: Anti-MC4-R/MC4R Antibody Picoband®

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-MC4-R/MC4R Antibody (ABIN7602763). Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human MC4-R/MC4R, which shares 88.5% and 80.8% amino acid (aa) sequence identity with mouse and rat MC4-R/MC4R, respectively.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
Immunocytochemistry/Immunofluorescence, 2 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
1. Hardy, R., Wills, A. K., Wong, A., Elks, C. E., Wareham, N. J., Loos, R. J. F., Kuh, D., Ong, K. K. Life course variations in the associations between FTO and MC4R gene variants and body size. Hum. Molec. Genet. 19: 545-552, 2010. 2. Hebebrand, J., Geller, F., Dempfle, A., Heinzel-Gutenbrunner, M., Raab, M., Gerber, G., Wermter, A.-K., Horro, F. F., Blundell, J., Schafer, H., Remschmidt, H., Herpertz, S., Hinney, A. Binge-eating episodes are not characteristic of carriers of melanocortin-4 receptor gene mutations. Molec. Psychiat. 9: 796-800, 2004. 3. Heid, I. M., Vollmert, C., Hinney, A., Doring, A., Geller, F., Lowel, H., Wichmann, H.-E., Illig, T., Hebebrand, J., Kronenberg, F., the KORA group. Association of the 1031 MC4R allele with decreased body mass in 7937 participants of two population based surveys. J. Med. Genet. 42: e21, 2005. Note: Electronic Article.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Details zu MC4R

Target: MC4R (Melanocortin 4 Receptor (MC4R))

Andere Bezeichnung: MC4R

Hintergrund:

Synonyms: Melanocortin receptor 4, MC4-R, MC4R

Tissue Specificity: Brain, placental, and gut tissues.

Background: Melanocortin receptor 4 is a protein that in humans is encoded by the MC4R gene. This gene is mapped to 18q21.32. The protein encoded by this gene is a membrane-bound receptor and member of the melanocortin receptor family. The encoded protein interacts with adrenocorticotropic and MSH hormones and is mediated by G proteins. This is an intronless gene. Defects in this gene are a cause of autosomal dominant obesity.

Molekulargewicht: 37 kDa

Gen-ID: 4160

UniProt: P32245

Pathways: Hormone Transport, cAMP Metabolic Process, Feeding Behaviour