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RTEL1 Antikörper (AA 98-1173)

RTEL1 Reaktivität: Human, Maus, Ratte ELISA, WB, FACS Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7602712
  • Target Alle RTEL1 Antikörper anzeigen
    RTEL1 (Regulator of Telomere Elongation Helicase 1 (RTEL1))
    Bindungsspezifität
    • 5
    • 4
    • 3
    • 1
    AA 98-1173
    Reaktivität
    Human, Maus, Ratte
    Wirt
    • 13
    Kaninchen
    Klonalität
    • 15
    Polyklonal
    Konjugat
    • 11
    • 2
    • 1
    • 1
    Dieser RTEL1 Antikörper ist unkonjugiert
    Applikation
    • 10
    • 8
    • 4
    • 2
    • 1
    ELISA, Western Blotting (WB), Flow Cytometry (FACS)
    Verwendungszweck
    Anti-RTEL1 Antibody Picoband®
    Kreuzreaktivität (Details)
    No cross-reactivity with other proteins.
    Produktmerkmale
    Anti-RTEL1 Antibody Picoband® (ABIN7602712). Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
    Aufreinigung
    Immunogen affinity purified.
    Immunogen
    E.coli-derived human RTEL1 recombinant protein (Position: D98-K1173).
    Isotyp
    IgG
    Top Product
    Discover our top product RTEL1 Primärantikörper
  • Applikationshinweise
    Western blot, 0.1-0.25 μg/mL, Human, Mouse, Rat
    Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
    ELISA, 0.1-0.5 μg/mL, -
    1. Ballew, B. J., Yeager, M., Jacobs, K., Giri, N., Boland, J., Burdett, L., Alter, B. P., Savage, S. A. Germline mutations of regulator of telomere elongation helicase 1, RTEL1, in dyskeratosis congenita. Hum. Genet. 132: 473-480, 2013. 2. Walne, A. J., Vulliamy, T., Kirwan, M., Plagnol, V., Dokal, I. Constitutional mutations in RTEL1 cause severe dyskeratosis congenita. Am. J. Hum. Genet. 92: 448-453, 2013.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Konzentration
    500 μg/mL
    Buffer
    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
  • Target
    RTEL1 (Regulator of Telomere Elongation Helicase 1 (RTEL1))
    Andere Bezeichnung
    RTEL1 (RTEL1 Produkte)
    Hintergrund

    Synonyms: Regulator of telomere elongation helicase 1

    Tissue Specificity: Most abundant in heart, brain, liver, skeletal muscle and testis but absent in thymus and peripheral blood leukocytes.

    Background: The RTEL1 gene encodes a DNA helicase which functions in the stability, protection and elongation of telomeres and interacts with proteins in the shelterin complex known to protect telomeres during DNA replication. Mutations in this gene have been associated with dyskeratosis congenita and Hoyerall-Hreidarsson syndrome. Read-through transcription of this gene into the neighboring downstream gene, which encodes tumor necrosis factor receptor superfamily, member 6b, generates a non-coding transcript. Alternative splicing results in multiple transcript variants encoding different isoforms.

    Molekulargewicht
    160 kDa
    Gen-ID
    51750
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