SOGA2 Antikörper (AA 884-1522)
Kurzübersicht für SOGA2 Antikörper (AA 884-1522) (ABIN7602600)
Target
Reaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 884-1522
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Verwendungszweck
- Anti-MTCL1 Antibody Picoband®
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Kreuzreaktivität (Details)
- No cross-reactivity with other proteins.
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Produktmerkmale
- Anti-MTCL1 Antibody Picoband® (ABIN7602600). Tested in ELISA, IHC, WB, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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Aufreinigung
- Immunogen affinity purified.
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Immunogen
- E.coli-derived human MTCL1 recombinant protein (Position: K884-D1522).
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Isotyp
- IgG
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Applikationshinweise
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Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
Immunohistochemistry, 2-5 μg/mL, Human, Mouse, Rat
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Hartz, P. A. Personal Communication. Baltimore, Md. 4/28/2014. 2. Nagase, T., Ishikawa, K., Suyama, M., Kikuno, R., Miyajima, N., Tanaka, A., Kotani, H., Nomura, N., Ohara, O. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 5: 277-286, 1998. 3. Sato, Y., Akitsu, M., Amano, Y., Yamashita, K., Ide, M., Shimada, K., Yamashita, A., Hirano, H., Arakawa, N., Maki, T., Hayashi, I., Ohno, S., Suzuki, A. The novel PAR-1-binding protein MTCL1 has crucial roles in organizing microtubules in polarizing epithelial cells. J. Cell Sci. 126: 4671-4683, 2013. -
Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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Konzentration
- 500 μg/mL
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Buffer
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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Lagerung
- 4 °C,-20 °C
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Informationen zur Lagerung
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- SOGA2 (SOGA Family Member 2 (SOGA2))
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Andere Bezeichnung
- MTCL1
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Hintergrund
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Synonyms: Interleukin-17B, IL-17B, Cytokine CX1, Cytokine-like protein ZCYTO7, Neuronal interleukin-17-related factor, Il17b, Nirf, Zcyto7
Tissue Specificity: Expressed in adult pancreas, small intestine, stomach, spinal cord and testis. Less pronounced expression in prostate, colon mucosal lining, and ovary.
Background: MTCL1 (microtubule cross-linking factor 1), also known as CCDC165 (Coiledcoil domain-containing protein 165), SOGA2 or MTCL1, is a 1,905 amino acid protein that localizes to the cell membrane, cytoplasm and cytoskeleton. MTCL1 is a microtubule-associated factor that plays a role in regulating polarization and microtubule dynamics as well as the development and maintenance of non-centrosomal microtubule bundles. MTCL1 is encoded by a gene that maps to chromosome 18 and is expressed as four isoforms due to alternative splicing events. Chromosome 18 encodes over 300 genes and contains about 76 million bases. Trisomy 18, or Edwards syndrome, is the second most common trisomy after Downs syndrome. Symptoms of Edwards syndrome include low birth weight, a variety of physical development defects, heart deformations and breathing difficulty. Translocation between chromosome 18 and 14 is the most common translocation in cancers, and occurs in follicular lymphomas. Niemann-Pick disease, hereditary hemorrhagic telangiectasia and erythropoietic protoporphyria are associated with chromosome 18. The TGFβ modulators, Smad2, Smad4 and Smad7 are encoded by chromosome 18.
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Molekulargewicht
- 270-300 kDa
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Gen-ID
- 23255
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UniProt
- Q9Y4B5
Target
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