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Meprin B Antikörper (AA 73-489)

Dieses Anti-Meprin B-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Meprin B in WB, IHC, ELISA und IF. Geeignet für Ratte, Human und Maus.
Produktnummer ABIN7602389

Kurzübersicht für Meprin B Antikörper (AA 73-489) (ABIN7602389)

Target

Alle Meprin B (MEP1B) Antikörper anzeigen
Meprin B (MEP1B) (Meprin A, beta (MEP1B))

Reaktivität

Ratte, Human, Maus

Wirt

  • 8
  • 1
Kaninchen

Klonalität

  • 8
  • 1
Polyklonal

Konjugat

  • 9
Dieser Meprin B Antikörper ist unkonjugiert

Applikation

  • 9
  • 8
  • 5
  • 5
  • 4
Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)
  • Bindungsspezifität

    • 3
    • 2
    • 2
    AA 73-489

    Verwendungszweck

    Anti-MEP1B Antibody Picoband®

    Produktmerkmale

    Anti-MEP1B Antibody Picoband® (ABIN7602389). Tested in WB, IF, IHC, ELISA applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    E.coli-derived human MEP1B recombinant protein (Position: H73-Q489). Human MEP1B shares 82.3% and 81.5% amino acid (aa) sequence identity with mouse and rat MEP1B, respectively.
  • Applikationshinweise

    Western blot, 0.25-0.5 μg/mL, Mouse, Rat
    Immunohistochemistry, 2-5 μg/mL, Mouse, Rat
    Immunofluorescence, 5 μg/mL, Mouse, Rat
    ELISA, 0.1-0.5 μg/mL, -
    1. Bond, J. S., Rojas, K., Overhauser, J., Zoghbi, H. Y., Jiang, W. The structural genes, MEP1A and MEP1B, for the alpha and beta subunits of the metalloendopeptidase meprin map to human chromosomes 6p and 18q, respectively. Genomics 25: 300-303, 1995. 2. Crisman, J. M., Zhang, B., Norman, L. P., Bond, J. S. Deletion of the mouse meprin beta metalloprotease gene diminishes the ability of leukocytes to disseminate through extracellular matrix. J. Immun. 172: 4510-4519, 2004. 3. Gorbea, C. M., Marchand, P., Jiang, W., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., Bond, J. S. Cloning, expression, and chromosomal localization of the mouse meprin beta subunit. J. Biol. Chem. 268: 21035-21043, 1993.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
  • Target

    Meprin B (MEP1B) (Meprin A, beta (MEP1B))

    Andere Bezeichnung

    MEP1B

    Hintergrund

    Meprin A subunit beta is a protein that in humans is encoded by the MEP1B gene. Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes, and in leukocytes and certain cancer cells. They are involved in the hydrolysis of a variety of peptide and protein substrates, and have been implicated in cancer and intestinal inflammation. Mature meprins are oligomers of evolutionarily related, but separately encoded alpha and/or beta subunits. Homooligomers of alpha subunit are secreted, whereas, oligomers containing the beta subunit are plasma membrane-bound. This gene encodes the beta subunit. Targeted disruption of this gene in mice affects embryonic viability, renal gene expression profiles, and distribution of the membrane-associated alpha subunit in kidney and intestine.

    Molekulargewicht

    97 kDa

    Gen-ID

    4225

    UniProt

    Q16820
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