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Meprin B Antikörper (AA 73-489)

MEP1B Reaktivität: Ratte, Human, Maus WB, IHC, ELISA, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7602389
  • Target Alle Meprin B (MEP1B) Antikörper anzeigen
    Meprin B (MEP1B) (Meprin A, beta (MEP1B))
    Bindungsspezifität
    • 3
    • 2
    • 2
    AA 73-489
    Reaktivität
    Ratte, Human, Maus
    Wirt
    • 8
    • 1
    Kaninchen
    Klonalität
    • 8
    • 1
    Polyklonal
    Konjugat
    • 9
    Dieser Meprin B Antikörper ist unkonjugiert
    Applikation
    • 9
    • 8
    • 5
    • 5
    • 4
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)
    Verwendungszweck
    Anti-MEP1B Antibody Picoband®
    Produktmerkmale
    Anti-MEP1B Antibody Picoband® (ABIN7602389). Tested in WB, IF, IHC, ELISA applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
    Aufreinigung
    Immunogen affinity purified.
    Immunogen
    E.coli-derived human MEP1B recombinant protein (Position: H73-Q489). Human MEP1B shares 82.3% and 81.5% amino acid (aa) sequence identity with mouse and rat MEP1B, respectively.
    Top Product
    Discover our top product MEP1B Primärantikörper
  • Applikationshinweise
    Western blot, 0.25-0.5 μg/mL, Mouse, Rat
    Immunohistochemistry, 2-5 μg/mL, Mouse, Rat
    Immunofluorescence, 5 μg/mL, Mouse, Rat
    ELISA, 0.1-0.5 μg/mL, -
    1. Bond, J. S., Rojas, K., Overhauser, J., Zoghbi, H. Y., Jiang, W. The structural genes, MEP1A and MEP1B, for the alpha and beta subunits of the metalloendopeptidase meprin map to human chromosomes 6p and 18q, respectively. Genomics 25: 300-303, 1995. 2. Crisman, J. M., Zhang, B., Norman, L. P., Bond, J. S. Deletion of the mouse meprin beta metalloprotease gene diminishes the ability of leukocytes to disseminate through extracellular matrix. J. Immun. 172: 4510-4519, 2004. 3. Gorbea, C. M., Marchand, P., Jiang, W., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., Bond, J. S. Cloning, expression, and chromosomal localization of the mouse meprin beta subunit. J. Biol. Chem. 268: 21035-21043, 1993.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Konzentration
    500 μg/mL
    Buffer
    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
  • Target
    Meprin B (MEP1B) (Meprin A, beta (MEP1B))
    Andere Bezeichnung
    MEP1B (MEP1B Produkte)
    Hintergrund
    Meprin A subunit beta is a protein that in humans is encoded by the MEP1B gene. Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes, and in leukocytes and certain cancer cells. They are involved in the hydrolysis of a variety of peptide and protein substrates, and have been implicated in cancer and intestinal inflammation. Mature meprins are oligomers of evolutionarily related, but separately encoded alpha and/or beta subunits. Homooligomers of alpha subunit are secreted, whereas, oligomers containing the beta subunit are plasma membrane-bound. This gene encodes the beta subunit. Targeted disruption of this gene in mice affects embryonic viability, renal gene expression profiles, and distribution of the membrane-associated alpha subunit in kidney and intestine.
    Molekulargewicht
    97 kDa
    Gen-ID
    4225
    UniProt
    Q16820
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