Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

MAEL Antikörper (AA 73-347)

Dieses Anti-MAEL-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von MAEL in ELISA, WB und FACS. Geeignet für Human.
Produktnummer ABIN7602386

Kurzübersicht für MAEL Antikörper (AA 73-347) (ABIN7602386)

Target

Alle MAEL Antikörper anzeigen
MAEL (Maelstrom Spermatogenic Transposon Silencer (MAEL))

Reaktivität

  • 8
  • 2
  • 2
Human

Wirt

  • 8
Kaninchen

Klonalität

  • 8
Polyklonal

Konjugat

  • 4
  • 2
  • 1
  • 1
Dieser MAEL Antikörper ist unkonjugiert

Applikation

  • 6
  • 3
  • 3
  • 1
  • 1
  • 1
  • 1
ELISA, Western Blotting (WB), Flow Cytometry (FACS)
  • Bindungsspezifität

    • 5
    • 3
    • 1
    AA 73-347

    Verwendungszweck

    Anti-MAEL Antibody Picoband®

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins.

    Produktmerkmale

    Anti-MAEL Antibody Picoband® (ABIN7602386). Tested in ELISA, WB, Flow Cytometry applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    E.coli-derived human MAEL recombinant protein (Position: E73-Q347).

    Isotyp

    IgG
  • Applikationshinweise

    Western blot, 0.25-0.5 μg/mL, Human
    Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
    ELISA, 0.1-0.5 μg/mL, -
    1. Findley, S. D., Tamanaha, M., Clegg, N. J., Ruohola-Baker, H. Maelstrom, a Drosophila spindle-class gene, encodes a protein that colocalizes with Vasa and RDE1/AGO1 homolog, Aubergine, in nuage. Development 130: 859-871, 2003. 2. Hartz, P. A. Personal Communication. Baltimore, Md. 7/29/2009. 3. Soper, S. F. C., van der Heijden, G. W., Hardiman, T. C., Goodheart, M., Martin, S. L., de Boer, P., Bortvin, A. Mouse Maelstrom, a component of nuage, is essential for spermatogenesis and transposon regression in meiosis. Dev. Cell 15: 285-297, 2008. [PubMed: 18694567, images, related citations] [Full Text]

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
  • Target

    MAEL (Maelstrom Spermatogenic Transposon Silencer (MAEL))

    Andere Bezeichnung

    MAEL

    Hintergrund

    Synonyms: FERM domain-containing protein 6, Willin, FRMD6, C14orf31

    Tissue Specificity: Expressed in fetal and adult brain. Also detected in fetal liver and skeletal muscle, but not in their adult counterparts.

    Background: The mammalian homolog of the Drosophila protein Maelstrom is expressed in the male germline and localizes to the sex body in spermatocytes and the chromatoid body in round spermatids. Similar to its expression in Drosophila, Maelstrom is a component of nuages, a germ-cell specific organelle and is thought to be essential for spermatogenesis and transposon repression during meiosis. In humans, Maelstrom has been found to be expressed only in the testis and in various cancer cell lines. Treatment of these cell lines with the demethylating agent 5'-Aza-2-Deoxycytidine significantly upregulated Maelstrom levels, indicating that its expression is regulated by DNA methylation.

    Molekulargewicht

    49 kDa

    Gen-ID

    84944
Sie sind hier:
Chat with us!