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MAEL Antikörper (AA 73-347)

MAEL Reaktivität: Human ELISA, WB, FACS Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7602386
  • Target Alle MAEL Antikörper anzeigen
    MAEL (Maelstrom Spermatogenic Transposon Silencer (MAEL))
    Bindungsspezifität
    • 5
    • 2
    • 1
    AA 73-347
    Reaktivität
    • 7
    • 1
    • 1
    Human
    Wirt
    • 7
    Kaninchen
    Klonalität
    • 7
    Polyklonal
    Konjugat
    • 3
    • 2
    • 1
    • 1
    Dieser MAEL Antikörper ist unkonjugiert
    Applikation
    • 6
    • 3
    • 2
    • 1
    • 1
    • 1
    ELISA, Western Blotting (WB), Flow Cytometry (FACS)
    Verwendungszweck
    Anti-MAEL Antibody Picoband®
    Kreuzreaktivität (Details)
    No cross-reactivity with other proteins.
    Produktmerkmale
    Anti-MAEL Antibody Picoband® (ABIN7602386). Tested in ELISA, WB, Flow Cytometry applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
    Aufreinigung
    Immunogen affinity purified.
    Immunogen
    E.coli-derived human MAEL recombinant protein (Position: E73-Q347).
    Isotyp
    IgG
    Top Product
    Discover our top product MAEL Primärantikörper
  • Applikationshinweise
    Western blot, 0.25-0.5 μg/mL, Human
    Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
    ELISA, 0.1-0.5 μg/mL, -
    1. Findley, S. D., Tamanaha, M., Clegg, N. J., Ruohola-Baker, H. Maelstrom, a Drosophila spindle-class gene, encodes a protein that colocalizes with Vasa and RDE1/AGO1 homolog, Aubergine, in nuage. Development 130: 859-871, 2003. 2. Hartz, P. A. Personal Communication. Baltimore, Md. 7/29/2009. 3. Soper, S. F. C., van der Heijden, G. W., Hardiman, T. C., Goodheart, M., Martin, S. L., de Boer, P., Bortvin, A. Mouse Maelstrom, a component of nuage, is essential for spermatogenesis and transposon regression in meiosis. Dev. Cell 15: 285-297, 2008. [PubMed: 18694567, images, related citations] [Full Text]
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Konzentration
    500 μg/mL
    Buffer
    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
  • Target
    MAEL (Maelstrom Spermatogenic Transposon Silencer (MAEL))
    Andere Bezeichnung
    MAEL (MAEL Produkte)
    Hintergrund

    Synonyms: FERM domain-containing protein 6, Willin, FRMD6, C14orf31

    Tissue Specificity: Expressed in fetal and adult brain. Also detected in fetal liver and skeletal muscle, but not in their adult counterparts.

    Background: The mammalian homolog of the Drosophila protein Maelstrom is expressed in the male germline and localizes to the sex body in spermatocytes and the chromatoid body in round spermatids. Similar to its expression in Drosophila, Maelstrom is a component of nuages, a germ-cell specific organelle and is thought to be essential for spermatogenesis and transposon repression during meiosis. In humans, Maelstrom has been found to be expressed only in the testis and in various cancer cell lines. Treatment of these cell lines with the demethylating agent 5'-Aza-2-Deoxycytidine significantly upregulated Maelstrom levels, indicating that its expression is regulated by DNA methylation.

    Molekulargewicht
    49 kDa
    Gen-ID
    84944
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