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NCOA6 Antikörper (AA 64-1475)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch NCOA6 in ELISA, WB, IF, FACS und ICC. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.
Produktnummer ABIN7602210

Kurzübersicht für NCOA6 Antikörper (AA 64-1475) (ABIN7602210)

Target

Alle NCOA6 Antikörper anzeigen
NCOA6 (Nuclear Receptor Coactivator 6 (NCOA6))

Reaktivität

  • 20
  • 9
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Human, Maus, Ratte

Wirt

  • 17
  • 3
Kaninchen

Klonalität

  • 18
  • 2
Polyklonal

Konjugat

  • 9
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser NCOA6 Antikörper ist unkonjugiert

Applikation

  • 8
  • 5
  • 5
  • 4
  • 3
  • 3
ELISA, Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunocytochemistry (ICC)
  • Bindungsspezifität

    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 64-1475

    Verwendungszweck

    Anti-NCOA6 Antibody Picoband®

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins

    Produktmerkmale

    Anti-NCOA6 Antibody Picoband® (ABIN7602210). Tested in WB, ICC/IF, Flow Cytometry, ELISA applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    E.coli-derived human NCOA6 recombinant protein (Position: K64-E1475). Human NCOA6 shares 92.1% amino acid (aa) sequence identity with mouse NCOA6.

    Isotyp

    IgG
  • Applikationshinweise

    Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
    Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
    Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
    ELISA, 0.1-0.5 μg/mL
    1. Antonson, P., Jakobsson, T., Almlof, T., Guldevall, K., Steffensen, K. R., Gustafsson, J.-A. RAP250 is a coactivator in the transforming growth factor beta signaling pathway that interacts with Smad2 and Smad3. J. Biol. Chem. 283: 8995-9001, 2008. 2. Antonson, P., Schuster, G. U., Wang, L., Rozell, B., Holter, E., Flodby, P., Treuter, E., Holmgren, L., Gustafsson, J.-A. Inactivation of the nuclear receptor coactivator RAP250 in mice results in placental vascular dysfunction. Molec. Cell. Biol. 23: 1260-1268, 2003. 3. Caira, F., Antonson, P., Pelto-Huikko, M., Treuter, E., Gustafsson, J.-A. Cloning and characterization of RAP250, a novel nuclear receptor coactivator. J. Biol. Chem. 275: 5308-5317, 2000.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
  • Target

    NCOA6 (Nuclear Receptor Coactivator 6 (NCOA6))

    Andere Bezeichnung

    NCOA6

    Hintergrund

    Synonyms: NCOA6, AIB3, KIAA0181, RAP250, TRBP, Nuclear receptor coactivator 6, Activating signal cointegrator 2, ASC-2, Amplified in breast cancer protein 3, Cancer-amplified transcriptional coactivator ASC-2, Nuclear receptor coactivator RAP250, NRC RAP250, Nuclear receptor-activating protein, 250 kDa, Peroxisome proliferator-activated receptor-interacting protein, PPAR-interacting protein, PRIP, Thyroid hormone receptor-binding protein

    Background: The protein encoded by this gene is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcriptional activator functions. This protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D3, thyroid hormone, and steroid receptors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

    Molekulargewicht

    250 kDa

    Gen-ID

    23054

    UniProt

    Q14686

    Pathways

    Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha
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