TULP3 Antikörper (AA 62-362)

Produktnummer ABIN7602191

Dieses Anti-TULP3-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von TULP3 in WB und ELISA. Geeignet für Human.

Kurzübersicht für TULP3 Antikörper (AA 62-362) (ABIN7602191)

Target: TULP3 (Tubby Like Protein 3 (TULP3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TULP3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-TULP3 Antikörper

Bindungsspezifität: AA 62-362

Verwendungszweck: Anti-TULP3 Antibody Picoband®

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-TULP3 Antibody Picoband® (ABIN7602191). Tested in ELISA, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human TULP3 recombinant protein (Position: P62-H362).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.25-0.5 μg/mL, Human
ELISA, 0.1-0.5 μg/mL, -
1. Devane, J., Ott, E., Olinger, E. G., Epting, D., Decker, E., Friedrich, A., Bachmann, N., Renschler, G., Eisenberger, T., Briem-Richter, A., Grabhorn, E. F., Powell, L., and 24 others. Progressive liver, kidney, and heart degeneration in children and adults affected by TULP3 mutations. Am. J. Hum. Genet. 109: 928-943, 2022. 2. Ikeda, A., Ikeda, S., Gridley, T., Nishina, P. M., Naggert, J. K. Neural tube defects and neuroepithelial cell death in Tulp3 knockout mice. Hum. Molec. Genet. 10: 1325-1334, 2001. 3. Nishina, P. M., North, M. A., Ikeda, A., Yan, Y., Naggert, J. K. Molecular characterization of a novel tubby gene family member, TULP3, in mouse and humans. Genomics 54: 215-220, 1998.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Details zu TULP3

Target: TULP3 (Tubby Like Protein 3 (TULP3))

Andere Bezeichnung: TULP3

Hintergrund:

Synonyms: B-cell differentiation antigen CD72, Lyb-2, CD72, CD72

Tissue Specificity: Pre-B-cells and B-cells but not terminally differentiated plasma cells.

Background: This gene encodes a member of the tubby gene family of bipartite transcription factors. Members of this family have been identified in plants, vertebrates, and invertebrates, and they share a conserved N-terminal transcription activation region and a conserved C-terminal DNA and phosphatidylinositol-phosphate binding region. The encoded protein binds to phosphoinositides in the plasma membrane via its C-terminal region and probably functions as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis, for instance, induced by G-protein-coupled-receptor signaling. It plays an important role in neuronal development and function. Two transcript variants encoding distinct isoforms have been identified for this gene.

Molekulargewicht: 60 kDa

Gen-ID: 7289

UniProt: O75386

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Tube Formation