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R-Spondin 4 Antikörper (AA 60-206)

Der Kaninchen Polyklonal Anti-R-Spondin 4-Antikörper wurde für WB, FACS und ELISA validiert. Er ist geeignet, R-Spondin 4 in Proben von Human, Maus und Ratte zu detektieren.
Produktnummer ABIN7602151

Kurzübersicht für R-Spondin 4 Antikörper (AA 60-206) (ABIN7602151)

Target

Alle R-Spondin 4 (RSPO4) Antikörper anzeigen
R-Spondin 4 (RSPO4)

Reaktivität

Human, Maus, Ratte

Wirt

  • 9
  • 1
Kaninchen

Klonalität

  • 9
  • 1
Polyklonal

Konjugat

  • 5
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser R-Spondin 4 Antikörper ist unkonjugiert

Applikation

  • 10
  • 9
  • 8
  • 8
  • 2
Western Blotting (WB), Flow Cytometry (FACS), ELISA
  • Bindungsspezifität

    • 8
    • 2
    • 1
    • 1
    AA 60-206

    Verwendungszweck

    Anti-RSPO4 Antibody Picoband®

    Kreuzreaktivität (Details)

    No cross reactivity with other proteins.

    Produktmerkmale

    Anti-RSPO4 Antibody Picoband® (ABIN7602151). Tested in WB, Flow Cytometry, ELISA applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    E.coli-derived human RSPO4 recombinant protein (Position: R60-K206). Human RSPO4 shares 82.2% amino acid (aa) sequence identity with mouse RSPO4.

    Isotyp

    IgG
  • Applikationshinweise

    Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
    Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
    ELISA, 0.1-0.5 μg/mL, -
    1. Bergmann, C., Senderek, J., Anhuf, D., Thiel, C. T., Ekici, A. B., Poblete-Gutierrez, P., van Steensel, M., Seelow, D., Nurnberg, G., Schild, H. H., Nurnberg, P., Reis, A., Frank, J., Zerres, K. Mutations in the gene encoding the Wnt-signaling component R-spondin 4 (RSPO4) cause autosomal recessive anonychia. Am. J. Hum. Genet. 79: 1105-1109, 2006. 2. Blaydon, D. C., Ishii, Y., O'Toole, E. A., Unsworth, H. C., Teh, M.-T., Ruschendorf, F., Sinclair, C., Hopsu-Havu, V. K., Tidman, N., Moss, C., Watson, R., de Berker, D., Wajid, M., Christiano, A. M., Kelsell, D. P. The gene encoding R-spondin 4 (RSPO4), a secreted protein implicated in Wnt signaling, is mutated in inherited anonychia. Nature Genet. 38: 1245-1247, 2006. 3. Bruchle, N. O., Frank, J., Frank, V., Senderek, J., Akar, A., Koc, E., Rigopoulos, D., van Steensel, M., Zerres, K., Bergmann, C. RSPO4 is the major gene in autosomal-recessive anonychia and mutations cluster in the furin-like cysteine-rich domains of the Wnt signaling ligand R-spondin 4. J. Invest. Derm. 128: 791-796, 2008.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
  • Target

    R-Spondin 4 (RSPO4)

    Andere Bezeichnung

    RSPO4

    Hintergrund

    Synonyms: 70 kDa ribosomal protein S6 kinase 1 antibody, KS6B1_HUMAN antibody, p70 alpha antibody, P70 beta 1 antibody, p70 ribosomal S6 kinase alpha antibody, p70 ribosomal S6 kinase beta 1 antibody, p70 S6 kinase alpha antibody, P70 S6 Kinase antibody, p70 S6 kinase alpha 1 antibody, p70 S6 kinase alpha 2 antibody, p70 S6K antibody, p70 S6K-alpha antibody, p70 S6KA antibody, p70(S6K) alpha antibody, p70(S6K)-alpha antibody, p70-alpha antibody, p70-S6K 1 antibody, p70-S6K antibody, P70S6K antibody, P70S6K1 antibody, p70S6Kb antibody, PS6K antibody, Ribosomal protein S6 kinase 70 kDa polypeptide 1 antibody, Ribosomal protein S6 kinase beta 1 antibody, Ribosomal protein S6 kinase beta-1 antibody, Ribosomal protein S6 kinase I antibody, RPS6KB1 antibody, S6K antibody, S6K-beta-1 antibody, S6K1 antibody, Serine/threonine kinase 14 alpha antibody, Serine/threonine-protein kinase 14A antibody, STK14A antibody

    Tissue Specificity: Expressed in all tissues.

    Background: For chromosome 20, R-spondin 4 is a protein in humans that is encoded by the RSPO4 gene. This gene encodes a member of the R-spondin family of proteins that share a common domain organization consisting of a signal peptide, cysteine-rich/furin-like domain, thrombospondin domain and a C-terminal basic region. The encoded protein may be involved in activation of Wnt/beta-catenin signaling pathways. Mutations in this gene are associated with anonychia congenital. Alternate splicing results in multiple transcript variants.

    Molekulargewicht

    26 kDa

    Gen-ID

    343637

    UniProt

    Q2I0M5
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