BLK Antikörper (AA 53-184)

Produktnummer ABIN7601971

Der Kaninchen Polyklonal Anti-BLK-Antikörper wurde für WB, ELISA und FACS validiert. Er ist geeignet, BLK in Proben von Human zu detektieren.

Kurzübersicht für BLK Antikörper (AA 53-184) (ABIN7601971)

Target: BLK (B Lymphoid Tyrosine Kinase (BLK))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BLK Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Produktdetails anti-BLK Antikörper

Bindungsspezifität: AA 53-184

Verwendungszweck: Anti-BLK Antibody Picoband®

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-BLK Antibody Picoband® (ABIN7601971). Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human BLK recombinant protein (Position: D53-E184).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.25-0.5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Appel, S., Filter, M., Reis, A., Hennies, H. C., Bergheim, A., Ogilvie, E., Arndt, S., Simmons, A., Lovett, M., Hide, W., Ramsay, M., Reichwald, K., Zimmermann, W., Rosenthal, A. Physical and transcriptional map of the critical region for keratolytic winter erythema (KWE) on chromosome 8p22-p23 between D8S550 and D8S1759. Europ. J. Hum. Genet. 10: 17-25, 2002. 2. Borowiec, M., Liew, C. W., Thompson, R., Boonyasrisawat, W., Hu, J., Mlynarski, W. M., El Khattabi, I., Kim, S.-H., Marselli, L., Rich, S. S., Krolewski, A. S., Bonner-Weir, S., Sharma, A., Sale, M., Mychaleckyj, J. C., Kulkarni, R. N., Doria, A. Mutations at the BLK locus linked to maturity onset diabetes of the young and beta-cell dysfunction. Proc. Nat. Acad. Sci. 106: 14460-14465, 2009. 3. Drebin, J. A., Hartzell, S. W., Griffin, C., Campbell, M. J., Niederhuber, J. E. Molecular cloning and chromosomal localization of the human homologue of a B-lymphocyte specific protein tyrosine kinase (blk). Oncogene 10: 477-486, 1995.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Details zu BLK

Target: BLK (B Lymphoid Tyrosine Kinase (BLK))

Andere Bezeichnung: BLK

Hintergrund:

Synonyms: Nuclear factor 1 B-type, NF1-B, Nuclear factor 1/B, CCAAT-box-binding transcription factor, CTF, Nuclear factor I/B, NF-I/B, NFI-B, TGGCA-binding protein, NFIB

Background: Tyrosine-protein kinase BLK, also known as B lymphocyte kinase, is a non-receptor tyrosine kinase that in humans is encoded by the BLK gene. This gene encodes a nonreceptor tyrosine-kinase of the src family of proto-oncogenes that are typically involved in cell proliferation and differentiation. The protein has a role in B-cell receptor signaling and B-cell development. The protein also stimulates insulin synthesis and secretion in response to glucose and enhances the expression of several pancreatic beta-cell transcription factors.

Molekulargewicht: 60 kDa

Gen-ID: 640

UniProt: P51451

Pathways: Positive Regulation of Peptide Hormone Secretion, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling