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XRN1 Antikörper (AA 523-1198)

Dieses Anti-XRN1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von XRN1 in WB, ICC, ELISA und IF. Geeignet für Human und Maus.
Produktnummer ABIN7601966

Kurzübersicht für XRN1 Antikörper (AA 523-1198) (ABIN7601966)

Target

Alle XRN1 Antikörper anzeigen
XRN1 (5'-3' Exoribonuclease 1 (XRN1))

Reaktivität

  • 20
  • 7
  • 4
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
Human, Maus

Wirt

  • 21
  • 1
Kaninchen

Klonalität

  • 21
  • 1
Polyklonal

Konjugat

  • 15
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser XRN1 Antikörper ist unkonjugiert

Applikation

  • 15
  • 6
  • 5
  • 5
  • 3
  • 2
  • 1
Western Blotting (WB), Immunocytochemistry (ICC), ELISA, Immunofluorescence (IF)
  • Bindungsspezifität

    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 523-1198

    Verwendungszweck

    Anti-XRN1 Antibody Picoband®

    Produktmerkmale

    Anti-XRN1 Antibody Picoband® (ABIN7601966). Tested in WB, ICC/IF, ELISA applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    E.coli-derived human XRN1 recombinant protein (Position: K523-H1198). Human XRN1 shares 93.2% amino acid (aa) sequence identity with mouse XRN1.
  • Applikationshinweise

    Western blot, 0.25-0.5 μg/mL, Human, Mouse
    Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
    ELISA, 0.1-0.5 μg/mL, -
    1. Bashkirov, V. I., Scherthan, H., Solinger, J. A., Buerstedde, J.-M., Heyer, W.-D. A mouse cytoplasmic exoribonuclease (mXRN1p) with preference for G4 tetraplex substrates. J. Cell Biol. 136: 761-773, 1997. 2. Gatfield, D., Izaurralde, E. Nonsense-mediated messenger RNA decay is initiated by endonucleolytic cleavage in Drosophila. Nature 429: 575-578, 2004. 3. Ingelfinger, D., Arndt-Jovin, D. J., Luhrmann, R., Achsel, T. The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrn1 in distinct cytoplasmic foci. RNA 8: 1489-1501, 2002.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
  • Target

    XRN1 (5'-3' Exoribonuclease 1 (XRN1))

    Andere Bezeichnung

    XRN1

    Hintergrund

    5'-3' exoribonuclease 1 (Xrn1) is a protein that in humans is encoded by the XRN1 gene. This gene encodes a member of the 5'-3' exonuclease family. The encoded protein may be involved in replication-dependent histone mRNA degradation, and interacts ly with the enhancer of mRNA-decapping protein 4. In addition to mRNA metabolism, a similar protein in yeast has been implicated in a variety of nuclear and cytoplasmic functions, including homologous recombination, meiosis, telomere maintenance, and microtubule assembly. Mutations in this gene are associated with osteosarcoma, suggesting that the encoded protein may also play a role in bone formation. Alternative splicing results in multiple transcript variants.

    Molekulargewicht

    200 kDa

    Gen-ID

    54464
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