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MCU Antikörper (AA 51-351)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch MCU in ELISA, IHC, WB und FACS. Er zeigt eine Reaktivität gegenüber Human, Maus, Ratte und Affe.
Produktnummer ABIN7601931

Kurzübersicht für MCU Antikörper (AA 51-351) (ABIN7601931)

Target

Alle MCU Antikörper anzeigen
MCU (Mitochondrial Calcium Uniporter (MCU))

Reaktivität

Human, Maus, Ratte, Affe

Wirt

  • 19
Kaninchen

Klonalität

  • 19
Polyklonal

Konjugat

  • 8
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser MCU Antikörper ist unkonjugiert

Applikation

ELISA, Immunohistochemistry (IHC), Western Blotting (WB), Flow Cytometry (FACS)
  • Bindungsspezifität

    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 51-351

    Verwendungszweck

    Anti-MCU Antibody Picoband®

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins.

    Produktmerkmale

    Anti-MCU Antibody Picoband® (ABIN7601931). Tested in ELISA, Flow Cytometry, IHC, WB applications. This antibody reacts with Human, Monkey, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    E.coli-derived human MCU recombinant protein (Position: V51-D351).

    Isotyp

    IgG
  • Applikationshinweise

    Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat, Monkey
    Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Human, Mouse, Rat
    Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
    ELISA, 0.1-0.5 μg/mL, -
    1. Baughman, J. M., Perocchi, F., Girgis, H. S., Plovanich, M., Belcher-Timme, C. A., Sancak, Y., Bao, X. R., Strittmatter, L., Goldberger, O., Bagorad, R. L., Koteliansky, V., Mootha, V. K. Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter. Nature 476: 341-345, 2011. 2. De Stefani, D., Raffaello, A., Teardo, E., Szabo, I., Rizzuto, R. A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter. Nature 476: 336-340, 2011. 3. Hartz, P. A. Personal Communication. Baltimore, Md. 8/31/2011.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.01 mg Sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Target

    MCU (Mitochondrial Calcium Uniporter (MCU))

    Andere Bezeichnung

    MCU

    Hintergrund

    Synonyms: Serine/threonine-protein kinase/endoribonuclease IRE1, Endoplasmic reticulum-to-nucleus signaling 1, Inositol-requiring protein 1, hIRE1p, Ire1-alpha, IRE1a, Serine/threonine-protein kinase, Endoribonuclease, ERN1

    Tissue Specificity: Ubiquitously expressed. High levels observed in pancreatic tissue.

    Background: The mitochondrial calcium uniporter (MCU) is a transmembrane protein that allows the passage of calcium ions from a cell's cytosol into mitochondria. Its activity is regulated by MICU1 and MICU2, which together with the MCU make up the mitochondrial calcium uniporter complex. This gene encodes a calcium transporter that localizes to the mitochondrial inner membrane. The encoded protein interacts with mitochondrial calcium uptake 1. Alternative splicing results in multiple transcript variants.

    Molekulargewicht

    34 kDa

    Gen-ID

    90550

    Pathways

    Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis
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