IRGM Antikörper (AA 50-333)
Kurzübersicht für IRGM Antikörper (AA 50-333) (ABIN7601903)
Target
Alle IRGM Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 50-333
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Verwendungszweck
- Anti-IRGM/Irgm1 Antibody Picoband®
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Kreuzreaktivität (Details)
- No cross-reactivity with other proteins.
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Produktmerkmale
- Anti-IRGM/Irgm1 Antibody Picoband® (ABIN7601903). Tested in ELISA, WB applications. This antibody reacts with Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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Aufreinigung
- Immunogen affinity purified.
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Immunogen
- E.coli-derived mouse IRGM/Irgm1 recombinant protein (Position: E50-K333).
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Isotyp
- IgG
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Applikationshinweise
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Western blot, 0.25-0.5 μg/mL, Mouse
ELISA, 0.1-0.5 μg/mL, -
1. Amre, D. K., Mack, D. R., Morgan, K., Krupoves, A., Costea, I., Lambrette, P., Grimard, G., Dong, J., Feguery, H., Bucionis, V., Deslandres, C., Levy, E., Seidman, E. G. Autophagy gene ATG16L1 but not IRGM is associated with Crohn's disease in Canadian children. Inflamm. Bowel Dis. 15: 501-507, 2009. 2. Bekpen, C., Hunn, J. P., Rohde, C., Parvanova, I., Guethlein, L., Dunn, D. M., Glowalla, E., Leptin, M., Howard, J. C. The interferon-inducible p47 (IRG) GTPases in vertebrates: Loss of the cell autonomous resistance mechanism in the human lineage. Genome Biol. 6: R92, 2005. Note: Electronic Article. 3. Brest, P., Lapaquette, P., Souidi, M., Lebrigand, K., Cesaro, A., Vouret-Craviari, V., Mari, B., Barbry, P., Mosnier, J.-F., Hebuterne, X., Harel-Bellan, A., Mograbi, B., Darfeuille-Michaud, A., Hofman, P. A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease. Nature Genet. 43: 242-245, 2011. -
Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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Konzentration
- 500 μg/mL
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Buffer
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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Lagerung
- 4 °C,-20 °C
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Informationen zur Lagerung
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- IRGM (Immunity-Related GTPase Family, M (IRGM))
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Andere Bezeichnung
- Irgm1
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Hintergrund
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Synonyms: NADH-ubiquinone oxidoreductase chain 2, NADH dehydrogenase subunit 2, Mtnd2, mt-Nd2, Nd2
Tissue Specificity: Ubiquitously expressed.
Background: Immunity-related GTPase family M protein (IRGM), also known as interferon-inducible protein 1 (IFI1), is an enzyme that in humans is IRGM gene. This gene encodes a member of the p47 immunity-related GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens. Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis. Alternative splicing results in multiple transcript variants encoding different isoforms.
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Molekulargewicht
- 45 kDa
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Gen-ID
- 15944
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UniProt
- Q60766
Target
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