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IRGM Antikörper (AA 50-333)

Dieses Anti-IRGM-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von IRGM in WB und ELISA. Geeignet für Maus.
Produktnummer ABIN7601903

Kurzübersicht für IRGM Antikörper (AA 50-333) (ABIN7601903)

Target

Alle IRGM Antikörper anzeigen
IRGM (Immunity-Related GTPase Family, M (IRGM))

Reaktivität

  • 36
  • 5
  • 2
Maus

Wirt

  • 33
  • 4
Kaninchen

Klonalität

  • 33
  • 4
Polyklonal

Konjugat

  • 12
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser IRGM Antikörper ist unkonjugiert

Applikation

  • 30
  • 14
  • 13
  • 13
  • 7
  • 5
  • 3
  • 1
  • 1
Western Blotting (WB), ELISA
  • Bindungsspezifität

    • 15
    • 7
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 50-333

    Verwendungszweck

    Anti-IRGM/Irgm1 Antibody Picoband®

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins.

    Produktmerkmale

    Anti-IRGM/Irgm1 Antibody Picoband® (ABIN7601903). Tested in ELISA, WB applications. This antibody reacts with Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    E.coli-derived mouse IRGM/Irgm1 recombinant protein (Position: E50-K333).

    Isotyp

    IgG
  • Applikationshinweise

    Western blot, 0.25-0.5 μg/mL, Mouse
    ELISA, 0.1-0.5 μg/mL, -
    1. Amre, D. K., Mack, D. R., Morgan, K., Krupoves, A., Costea, I., Lambrette, P., Grimard, G., Dong, J., Feguery, H., Bucionis, V., Deslandres, C., Levy, E., Seidman, E. G. Autophagy gene ATG16L1 but not IRGM is associated with Crohn's disease in Canadian children. Inflamm. Bowel Dis. 15: 501-507, 2009. 2. Bekpen, C., Hunn, J. P., Rohde, C., Parvanova, I., Guethlein, L., Dunn, D. M., Glowalla, E., Leptin, M., Howard, J. C. The interferon-inducible p47 (IRG) GTPases in vertebrates: Loss of the cell autonomous resistance mechanism in the human lineage. Genome Biol. 6: R92, 2005. Note: Electronic Article. 3. Brest, P., Lapaquette, P., Souidi, M., Lebrigand, K., Cesaro, A., Vouret-Craviari, V., Mari, B., Barbry, P., Mosnier, J.-F., Hebuterne, X., Harel-Bellan, A., Mograbi, B., Darfeuille-Michaud, A., Hofman, P. A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease. Nature Genet. 43: 242-245, 2011.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
  • Target

    IRGM (Immunity-Related GTPase Family, M (IRGM))

    Andere Bezeichnung

    Irgm1

    Hintergrund

    Synonyms: NADH-ubiquinone oxidoreductase chain 2, NADH dehydrogenase subunit 2, Mtnd2, mt-Nd2, Nd2

    Tissue Specificity: Ubiquitously expressed.

    Background: Immunity-related GTPase family M protein (IRGM), also known as interferon-inducible protein 1 (IFI1), is an enzyme that in humans is IRGM gene. This gene encodes a member of the p47 immunity-related GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens. Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis. Alternative splicing results in multiple transcript variants encoding different isoforms.

    Molekulargewicht

    45 kDa

    Gen-ID

    15944

    UniProt

    Q60766
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