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Calpain 3 Antikörper (AA 42-764)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Calpain 3 in WB und ELISA. Er zeigt eine Reaktivität gegenüber Human und Maus.
Produktnummer ABIN7601700

Kurzübersicht für Calpain 3 Antikörper (AA 42-764) (ABIN7601700)

Target

Alle Calpain 3 (CAPN3) Antikörper anzeigen
Calpain 3 (CAPN3)

Reaktivität

  • 30
  • 7
  • 6
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
Human, Maus

Wirt

  • 28
  • 3
Kaninchen

Klonalität

  • 28
  • 3
Polyklonal

Konjugat

  • 23
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser Calpain 3 Antikörper ist unkonjugiert

Applikation

  • 21
  • 11
  • 9
  • 4
  • 4
  • 3
  • 2
  • 2
  • 1
Western Blotting (WB), ELISA
  • Bindungsspezifität

    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 42-764

    Verwendungszweck

    Anti-Calpain 3/CAPN3 Antibody Picoband®

    Produktmerkmale

    Anti-Calpain 3/CAPN3 Antibody Picoband® (ABIN7601700). Tested in WB, Flow Cytometry, ELISA applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    E.coli-derived human Calpain 3/CAPN3 recombinant protein (Position: I42-D764). Human CAPN3 shares 93.5% and 94.2% amino acid (aa) sequence identity with mouse and rat CAPN3, respectively.
  • Applikationshinweise

    Western blot, 0.25-0.5 μg/mL, Mouse
    ELISA, 0.1-0.5 μg/mL, -
    1. Blazquez, L., Azpitarte, M., Saenz, A., Goicoechea, M., Otaegui, D., Ferrer, X., Illa, I., Gutierrez-Rivas, E., Vilchez, J. J., Lopez de Munain, A. Characterization of novel CAPN3 isoforms in white blood cells: an alternative approach for limb-girdle muscular dystrophy 2A diagnosis. Neurogenetics 9: 173-182, 2008. 2. Canki-Klain, N., Milic, A., Kovac, B., Trlaja, A., Grgicevic, D., Zurak, N., Fardeau, M., Leturcq, F., Kaplan, J.-C., Urtizberea, J. A., Politano, L., Piluso, G., Feingold, J. Prevalence of the 550delA mutation in calpainopathy (LGMD 2A) in Croatia. Am. J. Med. Genet. 125A: 152-156, 2004. Note: Erratum: Am. J. Med. Genet. 130A: 218 only, 2004. 3. Duno, M., Sveen, M.-L., Schwartz, M., Vissing, J. cDNA analyses of CAPN3 enhances mutation detection and reveals a low prevalence of LGMD2A patients in Denmark. Europ. J. Hum. Genet. 16: 935-940, 2008.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
  • Target

    Calpain 3 (CAPN3)

    Andere Bezeichnung

    Calpain 3/CAPN3

    Hintergrund

    Calpain-3 is a protein that in humans is encoded by the CAPN3 gene. Calpain, a heterodimer consisting of a large and a small subunit, is a major intracellular protease, although its function has not been well established. This gene encodes a muscle-specific member of the calpain large subunit family that specifically binds to titin. Mutations in this gene are associated with limb-girdle muscular dystrophies type 2A. Alternate promoters and alternative splicing result in multiple transcript variants encoding different isoforms and some variants are ubiquitously expressed.

    Molekulargewicht

    99 kDa

    Gen-ID

    825

    UniProt

    P20807

    Pathways

    Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
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