Myosin VI Antikörper (AA 383-786)

Produktnummer ABIN7601557

Der Kaninchen Polyklonal Anti-Myosin VI-Antikörper wurde für WB, ELISA und FACS validiert. Er ist geeignet, Myosin VI in Proben von Human und Maus zu detektieren.

Kurzübersicht für Myosin VI Antikörper (AA 383-786) (ABIN7601557)

Target: Myosin VI (MYO6)

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Myosin VI Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Produktdetails anti-Myosin VI Antikörper

Bindungsspezifität: AA 383-786

Verwendungszweck: Anti-MYO6 Antibody Picoband®

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-MYO6 Antibody Picoband® (ABIN7601557). Tested in ELISA, WB, Flow Cytometry applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human MYO6 recombinant protein (Position: Q383-H786).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.25-0.5 μg/mL, Human, Mouse
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Ahituv, N., Sobe, T., Robertson, N. G., Morton, C. C., Taggart, R. T., Avraham, K. B. Genomic structure of the human unconventional myosin VI gene. Gene 261: 269-275, 2000. 2. Ahmed, Z. M., Morell, R. J., Riazuddin, S., Gropman, A., Shaukat, S., Ahmad, M. M., Mohiddin, S. A., Fananapazir, L., Caruso, R. C., Husnain, T., Khan, S. N., Riazuddin, S., Griffith, A. J., Friedman, T. B., Wilcox, E. R. Mutations of MYO6 are associated with recessive deafness, DFNB37. Am. J. Hum. Genet. 72: 1315-1322, 2003. 3. Altman, D., Sweeney, H. L., Spudich, J. A. The mechanism of myosin VI translocation and its load-induced anchoring. Cell 116: 737-749, 2004.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Details zu Myosin VI

Target: Myosin VI (MYO6)

Andere Bezeichnung: MYO6

Hintergrund:

Synonyms: Homeobox protein SIX3,Sine oculis homeobox homolog 3,SIX3,

Tissue Specificity: Highly expressed in placenta, lung, kidney, testis and ovary. Weakly expressed in spleen and thymus. Not expressed in peripheral blood lymphocytes. Detected in hippocampus.

Background: Unconventional myosin-VI, is a protein that in humans is coded for by MYO6. This gene encodes a reverse-ion motor protein that moves toward the minus end of actin filaments and plays a role in intracellular vesicle and organelle transport. The protein consists of a motor domain containing an ATP- and an actin-binding site and a globular tail which interacts with other proteins. This protein maintains the structural integrity of inner ear hair cells and mutations in this gene cause non-syndromic autosomal dominant and recessive hearing loss. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Molekulargewicht: 150 kDa

Gen-ID: 4646

Pathways: Sensory Perception of Sound, Dicarboxylic Acid Transport, Asymmetric Protein Localization