ANTXR1 Antikörper (AA 33-301)

Produktnummer ABIN7601347

Der Kaninchen Polyklonal Anti-ANTXR1-Antikörper wurde für WB und ELISA validiert. Er ist geeignet, ANTXR1 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für ANTXR1 Antikörper (AA 33-301) (ABIN7601347)

Target: ANTXR1 (anthrax Toxin Receptor 1 (ANTXR1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ANTXR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-ANTXR1 Antikörper

Bindungsspezifität: AA 33-301

Verwendungszweck: Anti-TEM8/ATR/ANTXR1 Antibody Picoband®

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-TEM8/ATR/ANTXR1 Antibody Picoband® (ABIN7601347). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human TEM8/ATR/ANTXR1 recombinant protein (Position: E33-D301).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.25-0.5 μg/mL, Mouse, Rat
ELISA, 0.1-0.5 μg/mL, -
1. Baxova, A., Kozlowski, K., Obersztyn, E., Zeman, J. GAPO syndrome (radiographic clues to early diagnosis). Radiol. Med. 93: 289-291, 1997. 2. Bayram, Y., Pehlivan, D., Karaca, E., Gambin, T., Jhangiani, S. N., Erdin, S., Gonzaga-Jauregui, C., Wiszniewski, W., Muzny, D., Baylor-Hopkins Center for Mendelian Genomics, Elcioglu, N. H., Yildirim, M. S., Bozkurt, B., Zamani, A. G., Boerwinkle, E., Gibbs, R. A., Lupski, J. R.. Whole exome sequencing identifies three novel mutations in ANTXR1 in families with GAPO syndrome. Am. J. Med. Genet. 164A: 2328-2334, 2014. 3. Besschetnova, T. Y., Ichimura, T., Katebi, N., St. Croix, B., Bonventre, J. V., Olsen, B. R. Regulatory mechanisms of anthrax toxin receptor 1-dependent vascular and connective tissue homeostasis. Matrix Biol. 42: 56-73, 2015.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Details zu ANTXR1

Target: ANTXR1 (anthrax Toxin Receptor 1 (ANTXR1))

Andere Bezeichnung: ANTXR1

Hintergrund:

Synonyms: Voltage-dependent calcium channel subunit alpha-2/delta-2, Voltage-gated calcium channel subunit alpha-2/delta-2, Voltage-dependent calcium channel subunit alpha-2-2, Voltage-dependent calcium channel subunit delta-2, CACNA2D2, KIAA0558

Tissue Specificity: Predominantly present in cerebellar cortex. Present in various lung tumor cell lines, while it is absent in normal lung (at protein level). Highly expressed in heart, lung, testis, pancreas and skeletal muscle. Also expressed in kidney, liver, placenta and brain.

Background: Anthrax toxin receptor 1 (ANTXR1 or also known asTEM8) is a protein that in humans is encoded by the ANTXR1 gene. This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described.

Molekulargewicht: 80 kDa

Gen-ID: 84168

UniProt: Q9H6X2