SHISA7 Antikörper (AA 308-535)

Produktnummer ABIN7601243

Dieses Anti-SHISA7-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von SHISA7 in WB und ELISA. Geeignet für Human, Maus und Ratte.

Kurzübersicht für SHISA7 Antikörper (AA 308-535) (ABIN7601243)

Target: SHISA7 (Shisa Homolog 7 (SHISA7))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SHISA7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-SHISA7 Antikörper

Bindungsspezifität: AA 308-535

Verwendungszweck: Anti-SHISA7 Antibody Picoband®

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-SHISA7 Antibody Picoband® (ABIN7601243). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human SHISA7 recombinant protein (Position: Y308-E535).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.25-0.5 μg/mL, Mouse, Rat
ELISA, 0.1-0.5 μg/mL, -
1. Han, W., Li, J., Pelkey, K. A., Pandey, S., Chen, X., Wang, Y.-X., Wu, K., Ge, L., Li, T., Castellano, D., Liu, C., Wu, L.-G., Petralia, R. S., Lynch, J. W., McBain, C. J., Lu, W. Shisa7 is a GABAA receptor auxiliary subunit controlling benzodiazepine actions. Science 366: 246-250, 2019. 2. Hartz, P. A. Personal Communication. Baltimore, Md. 1/30/2017. 3. Pei, J., Grishin, N. V. Unexpected diversity in Shisa-like proteins suggests the importance of their roles as transmembrane adaptors. Cell. Signal. 24: 758-769, 2012.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.01 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Details zu SHISA7

Target: SHISA7 (Shisa Homolog 7 (SHISA7))

Andere Bezeichnung: SHISA7

Hintergrund:

Synonyms: Placenta-specific protein 9, PLAC9

Tissue Specificity: Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.

Background: Shisa7, a single-passing transmembrane protein, localizes at GABAergic inhibitory synapses and interacts with GABA-A receptors. Shisa7 controlled receptor abundance at synapses and sped up the channel deactivation kinetics. Shisa7 also potently enhanced the action of diazepam, a classic benzodiazepine, on GABA-A receptors. Genetic deletion of Shisa7 selectively impaired GABAergic transmission and diminished the effects of diazepam in mic

Molekulargewicht: 70 kDa

Gen-ID: 729956