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SURF1 Antikörper (AA 27-295)

Dieses Anti-SURF1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von SURF1 in WB, ELISA, IF, ICC und FACS. Geeignet für Human, Ratte, Maus und Affe.
Produktnummer ABIN7601006

Kurzübersicht für SURF1 Antikörper (AA 27-295) (ABIN7601006)

Target

Alle SURF1 Antikörper anzeigen
SURF1 (Surfeit 1 (SURF1))

Reaktivität

  • 22
  • 9
  • 7
  • 2
  • 2
  • 2
  • 1
Human, Ratte, Maus, Affe

Wirt

  • 24
  • 1
Kaninchen

Klonalität

  • 25
Polyklonal

Konjugat

  • 18
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser SURF1 Antikörper ist unkonjugiert

Applikation

  • 18
  • 9
  • 6
  • 6
  • 4
  • 3
  • 2
  • 1
  • 1
Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC), Flow Cytometry (FACS)
  • Bindungsspezifität

    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 27-295

    Verwendungszweck

    Anti-SURF1 Antibody Picoband®

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins.

    Produktmerkmale

    Anti-SURF1 Antibody Picoband® (ABIN7601006). Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human, Monkey, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    E.coli-derived human SURF1 recombinant protein (Position: S27-R295).

    Isotyp

    IgG
  • Applikationshinweise

    Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
    Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
    Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
    ELISA, 0.1-0.5 μg/mL, -
    1. Agostino, A., Invernizzi, F., Tiveron, C., Fagiolari, G., Prelle, A., Lamantea, E., Giavazzi, A., Battaglia, G., Tatangelo, L., Tiranti, V., Zeviani, M. Constitutive knockout of Surf1 is associated with high embryonic lethality, mitochondrial disease and cytochrome c oxidase deficiency in mice. Hum. Molec. Genet. 12: 399-413, 2003. 2. Bohm, M., Pronicka, E., Karczmarewicz, E., Pronicki, M., Piekutowska-Abramczuk, D., Sykut-Cegielska, J., Mierzewska, H., Hansikova, H., Vesela, K., Tesarova, M., Houstkova, H., Houstek, J., Zeman, J. Retrospective, multicentric study of 180 children with cytochrome c oxidase deficiency. Pediat. Res. 59: 21-26, 2006. 3. Colombo, P., Yon, J., Garson, K., Fried, M. Conservation of the organization of five tightly clustered genes over 600 million years of divergent evolution. Proc. Nat. Acad. Sci. 89: 6358-6362, 1992.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
  • Target

    SURF1 (Surfeit 1 (SURF1))

    Andere Bezeichnung

    SURF1

    Hintergrund

    Synonyms: p-selectin glycoprotein ligand, Selplg, Psgl1

    Tissue Specificity: Highly expressed in blood, bone marrow, brain, adipose tissue, spleen, and thymus. Also expressed in heart, kidney, liver, muscle, ovary, and stomach.

    Background: Surfeit locus protein 1 (SURF1) is a protein that in humans is encoded by the SURF1 gene. This gene encodes a protein localized to the inner mitochondrial membrane and thought to be involved in the biogenesis of the cytochrome c oxidase complex. The protein is a member of the SURF1 family, which includes the related yeast protein SHY1 and rickettsial protein RP733. The gene is located in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity, where it shares a biional promoter with SURF2 on the opposite strand. Defects in this gene are a cause of Leigh syndrome, a severe neurological disorder that is commonly associated with systemic cytochrome c oxidase deficiency.

    Molekulargewicht

    33 kDa

    Gen-ID

    6834

    UniProt

    Q15526

    Pathways

    Proton Transport, Ribonucleoside Biosynthetic Process
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