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SURF1 Antikörper (AA 27-295)

SURF1 Reaktivität: Human, Ratte, Maus, Affe WB, ELISA, IF, ICC, FACS Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7601006
  • Target Alle SURF1 Antikörper anzeigen
    SURF1 (Surfeit 1 (SURF1))
    Bindungsspezifität
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 27-295
    Reaktivität
    • 22
    • 9
    • 7
    • 2
    • 2
    • 2
    • 1
    Human, Ratte, Maus, Affe
    Wirt
    • 24
    • 1
    Kaninchen
    Klonalität
    • 25
    Polyklonal
    Konjugat
    • 18
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SURF1 Antikörper ist unkonjugiert
    Applikation
    • 18
    • 9
    • 6
    • 6
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC), Flow Cytometry (FACS)
    Verwendungszweck
    Anti-SURF1 Antibody Picoband®
    Kreuzreaktivität (Details)
    No cross-reactivity with other proteins.
    Produktmerkmale
    Anti-SURF1 Antibody Picoband® (ABIN7601006). Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human, Monkey, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
    Aufreinigung
    Immunogen affinity purified.
    Immunogen
    E.coli-derived human SURF1 recombinant protein (Position: S27-R295).
    Isotyp
    IgG
    Top Product
    Discover our top product SURF1 Primärantikörper
  • Applikationshinweise
    Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
    Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
    Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
    ELISA, 0.1-0.5 μg/mL, -
    1. Agostino, A., Invernizzi, F., Tiveron, C., Fagiolari, G., Prelle, A., Lamantea, E., Giavazzi, A., Battaglia, G., Tatangelo, L., Tiranti, V., Zeviani, M. Constitutive knockout of Surf1 is associated with high embryonic lethality, mitochondrial disease and cytochrome c oxidase deficiency in mice. Hum. Molec. Genet. 12: 399-413, 2003. 2. Bohm, M., Pronicka, E., Karczmarewicz, E., Pronicki, M., Piekutowska-Abramczuk, D., Sykut-Cegielska, J., Mierzewska, H., Hansikova, H., Vesela, K., Tesarova, M., Houstkova, H., Houstek, J., Zeman, J. Retrospective, multicentric study of 180 children with cytochrome c oxidase deficiency. Pediat. Res. 59: 21-26, 2006. 3. Colombo, P., Yon, J., Garson, K., Fried, M. Conservation of the organization of five tightly clustered genes over 600 million years of divergent evolution. Proc. Nat. Acad. Sci. 89: 6358-6362, 1992.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Konzentration
    500 μg/mL
    Buffer
    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
  • Target
    SURF1 (Surfeit 1 (SURF1))
    Andere Bezeichnung
    SURF1 (SURF1 Produkte)
    Hintergrund

    Synonyms: p-selectin glycoprotein ligand, Selplg, Psgl1

    Tissue Specificity: Highly expressed in blood, bone marrow, brain, adipose tissue, spleen, and thymus. Also expressed in heart, kidney, liver, muscle, ovary, and stomach.

    Background: Surfeit locus protein 1 (SURF1) is a protein that in humans is encoded by the SURF1 gene. This gene encodes a protein localized to the inner mitochondrial membrane and thought to be involved in the biogenesis of the cytochrome c oxidase complex. The protein is a member of the SURF1 family, which includes the related yeast protein SHY1 and rickettsial protein RP733. The gene is located in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity, where it shares a biional promoter with SURF2 on the opposite strand. Defects in this gene are a cause of Leigh syndrome, a severe neurological disorder that is commonly associated with systemic cytochrome c oxidase deficiency.

    Molekulargewicht
    33 kDa
    Gen-ID
    6834
    UniProt
    Q15526
    Pathways
    Proton Transport, Ribonucleoside Biosynthetic Process
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