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UGT1A6 Antikörper (AA 27-251)

Dieses Anti-UGT1A6-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von UGT1A6 in ELISA, WB, IF und ICC. Geeignet für Human.
Produktnummer ABIN7601003

Kurzübersicht für UGT1A6 Antikörper (AA 27-251) (ABIN7601003)

Target

Alle UGT1A6 Antikörper anzeigen
UGT1A6 (UDP Glucuronosyltransferase 1 Family, Polypeptide A6 (UGT1A6))

Reaktivität

  • 24
  • 6
  • 5
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Human

Wirt

  • 22
  • 3
Kaninchen

Klonalität

  • 23
  • 2
Polyklonal

Konjugat

  • 15
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser UGT1A6 Antikörper ist unkonjugiert

Applikation

  • 12
  • 9
  • 5
  • 1
  • 1
  • 1
  • 1
ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)
  • Bindungsspezifität

    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 27-251

    Verwendungszweck

    Anti-UGT1A6 Antibody Picoband®

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins.

    Produktmerkmale

    Anti-UGT1A6 Antibody Picoband® (ABIN7601003). Tested in ELISA, IF, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    E.coli-derived human UGT1A6 recombinant protein (Position: D27-S251).

    Isotyp

    IgG
  • Applikationshinweise

    "Western blot, 0.25-0.5 μg/mL, Human
    Immunocytochemistry/Immunofluorescence, 2 μg/mL, Human
    ELISA, 0.1-0.5 μg/mL, -
    "1. Mackenzie PI, Owens IS, Burchell B, Bock KW, Bairoch A, Bélanger A, Fournel-Gigleux S, Green M, Hum DW, Iyanagi T, Lancet D, Louisot P, Magdalou J, Chowdhury JR, Ritter JK, Schachter H, Tephly TR, Tipton KF, Nebert DW (August 1997). "The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence". Pharmacogenetics. 7 (4): 255-69. 2. Ritter JK, Chen F, Sheen YY, Tran HM, Kimura S, Yeatman MT, Owens IS (February 1992). "A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini". The Journal of Biological Chemistry. 267 (5): 3257-61. 3. Shrestha B, Reed JM, Starks PT, Kaufman GE, Goldstone JV, Roelke ME, O'Brien SJ, Koepfli KP, Frank LG, Court MH (2011). Zanger U (ed.). "Evolution of a major drug metabolizing enzyme defect in the domestic cat and other felidae: phylogenetic timing and the role of hypercarnivory". PLoS One. 6 (3): e18046.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Target

    UGT1A6 (UDP Glucuronosyltransferase 1 Family, Polypeptide A6 (UGT1A6))

    Andere Bezeichnung

    UGT1A6

    Hintergrund

    Synonyms: "UDP-glucuronosyltransferase 1-5, UDPGT 1-5, UGT1*5, UGT1-05, UGT1.5, UDP-glucuronosyltransferase 1-E, UGT-1E, UGT1E, UDP-glucuronosyltransferase 1A5, UGT1A5, GNT1, UGT1

    Tissue Specificity: Expressed in skin. Isoforms 1 and 3 are expressed in kidney and liver. Isoform 1 but not isoform 2 is expressed in colon, esophagus and small intestine.

    Background: UDP-glucuronosyltransferase 1-6 is an enzyme that in humans is encoded by the UGT1A6 gene. It is mapped to 2q37.1. This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenolic and planar compounds. Alternative splicing in the unique 5' end of this gene results in two transcript variants.

    Molekulargewicht

    55-61 kDa

    Gen-ID

    54578

    UniProt

    P19224

    Pathways

    Steroid Hormone Biosynthesis, Regulation of Lipid Metabolism by PPARalpha
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