Azurocidin Antikörper (AA 27-245)

Produktnummer ABIN7601000

Dieses Anti-Azurocidin-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Azurocidin in WB, IHC, ELISA und FACS. Geeignet für Human, Maus und Ratte.

Kurzübersicht für Azurocidin Antikörper (AA 27-245) (ABIN7601000)

Target: Azurocidin (AZU1) (Azurocidin 1 (AZU1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Azurocidin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)

Produktdetails anti-Azurocidin Antikörper

Bindungsspezifität: AA 27-245

Verwendungszweck: Anti-Azurocidin/AZU1 Antibody Picoband®

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-Azurocidin/AZU1 Antibody Picoband® (ABIN7601000). Tested in ELISA, Flow Cytometry, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human Azurocidin/AZU1 recombinant protein (Position: I27-N245).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.25-0.5 μg/mL, Mouse, Rat
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Morgan, J. G. , Sukiennicki, T. , Pereira, H. A. , Spitznagel, J. K. , & Larrick, J. W. . (1991). Cloning of the cdna for the serine protease homolog cap37/azurocidin, a microbicidal and chemotactic protein from human granulocytes. The Journal of Immunology, 147(9), 3210-3214. 2. M, Zimmer, R, L, Medcalf, & T, et al. (1992). Three human elastase-like genes coordinately expressed in the myelomonocyte lineage are organized as a single genetic locus on 19pter. Proceedings of the National Academy of Sciences of the United States of America. 3. Gautam, N. , Olofsson, A. M. , Herwald, H. , Iversen, L. F. , & Lindbom, L. . (2001). Heparin-binding protein (hbp/cap37): a missing link in neutrophil-evoked alteration of vascular permeability. Nature Medicine, 7(10), 1123.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Details zu Azurocidin

Target: Azurocidin (AZU1) (Azurocidin 1 (AZU1))

Andere Bezeichnung: AZU1

Hintergrund:

Synonyms: Mucin-7, MUC-7, Apo-MG2, Salivary mucin-7, MUC7, MG2

Tissue Specificity: Expressed in salivary gland tissues and only in those that contain mucous acinar cells (e.g. sublingual and submandibular glands) and not in salivary glands containing only serous acinar cells (e.g. parotid gland).

Background: Azurocidin also known as cationic antimicrobial protein CAP37 or heparin-binding protein (HBP) is a protein that in humans is encoded by the AZU1 gene. Azurophil granules, specialized lysosomes of the neutrophil, contain at least 10 proteins implicated in the killing of microorganisms. This gene encodes a preproprotein that is proteolytically processed to generate a mature azurophil granule antibiotic protein, with monocyte chemotactic and antimicrobial activity. It is also an important multifunctional inflammatory mediator. This encoded protein is a member of the serine protease gene family but it is not a serine proteinase, because the active site serine and histidine residues are replaced. The genes encoding this protein, neutrophil elastase 2, and proteinase 3 are in a cluster located at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation.

Molekulargewicht: 37 kDa

Gen-ID: 566

UniProt: P20160