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PYROXD1 Antikörper (AA 26-453)

PYROXD1 Reaktivität: Human, Ratte, Maus WB, ELISA, FACS, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7600963
  • Target Alle PYROXD1 Produkte
    PYROXD1 (Pyridine Nucleotide-Disulphide Oxidoreductase Domain 1 (PYROXD1))
    Bindungsspezifität
    • 2
    • 1
    • 1
    AA 26-453
    Reaktivität
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Ratte, Maus
    Wirt
    • 4
    • 1
    Kaninchen
    Klonalität
    • 5
    Polyklonal
    Konjugat
    • 5
    Dieser PYROXD1 Antikörper ist unkonjugiert
    Applikation
    Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Verwendungszweck
    Anti-PYROXD1 Antibody Picoband®
    Kreuzreaktivität (Details)
    No cross-reactivity with other proteins.
    Produktmerkmale
    Anti-PYROXD1 Antibody Picoband® (ABIN7600963). Tested in ELISA, IF, ICC, WB, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
    Aufreinigung
    Immunogen affinity purified.
    Immunogen
    E.coli-derived human PYROXD1 recombinant protein (Position: A26-N453).
    Isotyp
    IgG
  • Applikationshinweise
    Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
    Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
    Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
    ELISA, 0.1-0.5 μg/mL, -
    1. O'Grady, G. L., Best, H. A., Sztal, T. E., Schartner, V., Sanjuan-Vazquez, M., Donkervoort, S., Neto, O. A., Sutton, R. B., Ilkovski, B., Romero, N. B., Stojkovic, T., Dastgir, J., and 30 others. Variants in the oxidoreductase PYROXD1 cause early-onset myopathy with internalized nuclei and myofibrillar disorganization. Am. J. Hum. Genet. 99: 1086-1105, 2016. 2. Zhang, J.-L., Zhao, W.-G., Wu, K.-L., Wang, K., Zhang, X., Gu, C.-F., Li, Y., Zhu, Y., Wu, J.-G. Human hepatitis B virus X protein promotes cell proliferation and inhibits cell apoptosis through interacting with a serine protease Hepsin. Arch. Virol. 150: 721-741, 2005.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Konzentration
    500 μg/mL
    Buffer
    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
  • Target
    PYROXD1 (Pyridine Nucleotide-Disulphide Oxidoreductase Domain 1 (PYROXD1))
    Andere Bezeichnung
    PYROXD1 (PYROXD1 Produkte)
    Hintergrund

    Synonyms: Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1, PYROXD1

    Tissue Specificity: Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.

    Background: Pyridine nucleotide-disulphide oxidoreductase domain 1 is a protein that in humans is encoded by the PYROXD1 gene. It is mapped to 12p12.1. This gene encodes a nuclear-cytoplasmic pyridine nucleotide-disulphide reductase (PNDR). PNDRs are flavoproteins that catalyze the pyridine nucleotide-dependent reduction of thiol residues in other proteins. The encoded protein belongs to the class I pyridine nucleotide-disulphide oxidoreductase family but lacks the C-terminal dimerization domain found in other family members and instead has a C-terminal nitrile reductase domain. It localizes to the nucleus and to striated sarcomeric compartments. Naturally occurring mutations in this gene cause early-onset myopathy with internalized nuclei and myofibrillar disorganization. A pseudogene of this gene has been defined on chromosome 11.

    Molekulargewicht
    65 kDa
    Gen-ID
    79912
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