FGF15 Antikörper (AA 26-218)

Produktnummer ABIN7600946

Produktdetails anti-FGF15 Antikörper

Target: FGF15 (Fibroblast Growth Factor 15 (FGF15))

Bindungsspezifität: AA 26-218

Reaktivität: Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FGF15 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Verwendungszweck: Anti-Fgf19(Fgf15) Antibody

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-Fgf19(Fgf15) Antibody Picoband® (ABIN7600946). Tested in IHC applications. This antibody reacts with Mouse, Rat.

Aufreinigung: Immunogen affinity purified.

Immunogen: E. coli-derived rat Fgf19(Fgf15) recombinant protein (Position: R26-K218). Rat Fgf19(Fgf15) shares 53.2% and 96.4% amino acid (aa) sequence identity with human and mouse FGF19, respectively.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Mouse, Rat
1. Jones, SA (2012). "Physiology of FGF15/19". Advances in Experimental Medicine and Biology. 728: 171-82. 2. Potthoff, MJ, Kliewer, SA, Mangelsdorf, DJ (2012). "Endocrine fibroblast growth factors 15/19 and 21: from feast to famine". Genes & Development. 26 (4): 312-324. 3. Owen, BM, Mangelsdorf, DJ, Kliewer, SA (January 2015). "Tissue-specific actions of the metabolic hormones FGF15/19 and FGF21". Trends in Endocrinology and Metabolism. 26 (1): 22-9.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Details zu FGF15

Target: FGF15 (Fibroblast Growth Factor 15 (FGF15))

Andere Bezeichnung: Fgf19(Fgf15) (FGF15 Produkte)

Hintergrund:

Synonyms: Fibroblast growth factor 19,FGF-19,FGF19,UNQ334/PRO533,

Tissue Specificity: Expressed in fetal brain, cartilage, retina, and adult gall bladder. .

Background: FGF15/19 refers to two orthologous fibroblast growth factors which share 50 % aminoacid identity and have similar functions. FGF15 was described in the mouse, FGF19 was found in humans and other species. They share physiological functions and so are often referred to as FGF15/19 or as FGF15/FGF19. They were first described in developing fetal brain. They are now known to be produced in the ileum, and under certain circumstances in the liver and biliary tree. It is thought their principal function is in response to bile acid absorption occurring after meals. FGF15 and FGF19 have similar roles in regulating bile acid synthesis and also glucose metabolism in the liver.

Molekulargewicht: 24 kDa

Gen-ID: 170582, 14170