Innate Immunity Activator Protein (C1ORF106) (AA 236-663) Antikörper

Produktnummer ABIN7600790

Dieser Anti-Innate Immunity Activator Protein-Antikörper ist ein Kaninchen-Polyklonal-Antikörper zum Nachweis von Innate Immunity Activator Protein in ELISA und WB. Geeignet für Human.

Kurzübersicht für Innate Immunity Activator Protein (C1ORF106) (AA 236-663) Antikörper (ABIN7600790)

Target: Innate Immunity Activator Protein (C1ORF106)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: ELISA, Western Blotting (WB)

Produktdetails

Bindungsspezifität: AA 236-663

Verwendungszweck: Anti-INAVA Antibody

Produktmerkmale: Anti-INAVA Antibody (ABIN7600790). Tested in WB, ELISA applications. This antibody reacts with Human. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human INAVA recombinant protein (Position: Q236-V663). Human INAVA shares 85.3% amino acid (aa) sequence identity with mouse INAVA.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.25-0.5 μg/mL, Human
ELISA, 0.1-0.5 μg/mL, -

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Antigendetails

Target: Innate Immunity Activator Protein (C1ORF106)

Andere Bezeichnung: INAVA

Hintergrund: INAVA, sometimes referred to as hypothetical protein LOC55765, is a protein of unknown function that in humans is encoded by the INAVA gene. Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion (PubMed:28436939). In the intestine, regulates adherens junction stability by regulating the degradation of CYTH1 and CYTH2, probably acting as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes. Stabilizes adherens junctions by limiting CYTH1-dependent ARF6 activation (PubMed:29420262).

Molekulargewicht: 70 kDa

Gen-ID: 55765