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NUP133 Antikörper (AA 228-1156)

NUP133 Reaktivität: Human, Maus, Ratte WB, IP, ELISA, ICC, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7600723
  • Target Alle NUP133 Antikörper anzeigen
    NUP133 (Nucleoporin 133kDa (NUP133))
    Bindungsspezifität
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 228-1156
    Reaktivität
    Human, Maus, Ratte
    Wirt
    • 12
    • 4
    Kaninchen
    Klonalität
    • 12
    • 4
    Polyklonal
    Konjugat
    • 16
    Dieser NUP133 Antikörper ist unkonjugiert
    Applikation
    • 15
    • 9
    • 8
    • 7
    • 5
    • 3
    • 1
    Western Blotting (WB), Immunoprecipitation (IP), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)
    Verwendungszweck
    Anti-NUP133 Antibody Picoband®
    Kreuzreaktivität (Details)
    No cross-reactivity with other proteins.
    Produktmerkmale
    Anti-N Antibody Picoband® (ABIN7600723). Tested in ELISA, IP, IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
    Aufreinigung
    Immunogen affinity purified.
    Immunogen
    E.coli-derived human NUP133 recombinant protein (Position: Q228-I1156).
    Isotyp
    IgG
    Top Product
    Discover our top product NUP133 Primärantikörper
  • Applikationshinweise
    Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
    Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human, Rat
    Immunoprecipitation, 0.5-2 μg/mL, Human
    ELISA, 0.1-0.5 μg/mL, -
    1. Belgareh, N., Rabut, G., Bai, S. W., van Overbeek, M., Beaudouin, J., Daigle, N., Zatsepina, O. V., Pasteau, F., Labas, V., Fromont-Racine, M., Ellenberg, J., Doye, V. An evolutionarily conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells. J. Cell. Biol. 154: 1147-1160, 2001. 2. Braun, D. A., Lovric, S., Schapiro, D., Schneider, R., Marquez, J., Asif, M., Hussain, M. S., Daga, A., Widneier, E., Rao, J., Ashraf, S., Tan, W., and 46 others. Mutations in multiple components of the nuclear pore complex cause nephrotic syndrome. J. Clin. Invest. 128: 4313-4328, 2018. 3. Fujita, A., Tsukaguchi, H., Koshimizu, E., Nakazato, H., Itoh, K., Kuraoka, S., Komohara, Y., Shiina, M., Nakamura, S., Kitajima, M., Tsurusaki, Y., Miyatake, S., Ogata, K., Iijima, K., Matsumoto, N., Miyake, N. Homozygous splicing mutation in NUP133 causes Galloway-Mowat syndrome. Ann. Neurol. 84: 814-828, 2018. Note: Erratum: Ann. Neurol. 85: 462-463, 2019.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Konzentration
    500 μg/mL
    Buffer
    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
  • Target
    NUP133 (Nucleoporin 133kDa (NUP133))
    Andere Bezeichnung
    NUP133 (NUP133 Produkte)
    Hintergrund

    Synonyms: Cytoskeleton-associated protein 5, Colonic and hepatic tumor overexpressed gene protein, Ch-TOG, CKAP5, KIAA0097

    Tissue Specificity: Overexpressed in hepatomas and colonic tumors. Also expressed in skeletal muscle, brain, heart, placenta, lung, liver, kidney and pancreas. Expression is elevated in the brain, highly expressed in the Purkinje cell bodies of the cerebellum.

    Background: Nuclear pore complex protein Nup133, or Nucleoporin Nup133, is a protein that in humans is encoded by the NUP133 gene. The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. The nucleoporin protein encoded by this gene displays evolutionarily conserved interactions with other nucleoporins. This protein, which localizes to both sides of the nuclear pore complex at interphase, remains associated with the complex during mitosis and is targeted at early stages to the reforming nuclear envelope. This protein also localizes to kinetochores of mitotic cells.

    Molekulargewicht
    129 kDa
    Gen-ID
    55746
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