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NUP133 Antikörper (AA 228-1156)

Der Kaninchen Polyklonal Anti-NUP133-Antikörper wurde für WB, IP, ELISA, ICC und IF validiert. Er ist geeignet, NUP133 in Proben von Human, Maus und Ratte zu detektieren.
Produktnummer ABIN7600723

Kurzübersicht für NUP133 Antikörper (AA 228-1156) (ABIN7600723)

Target

Alle NUP133 Antikörper anzeigen
NUP133 (Nucleoporin 133kDa (NUP133))

Reaktivität

Human, Maus, Ratte

Wirt

  • 12
  • 4
Kaninchen

Klonalität

  • 12
  • 4
Polyklonal

Konjugat

  • 16
Dieser NUP133 Antikörper ist unkonjugiert

Applikation

  • 15
  • 9
  • 8
  • 7
  • 5
  • 3
  • 1
Western Blotting (WB), Immunoprecipitation (IP), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)
  • Bindungsspezifität

    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 228-1156

    Verwendungszweck

    Anti-NUP133 Antibody Picoband®

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins.

    Produktmerkmale

    Anti-N Antibody Picoband® (ABIN7600723). Tested in ELISA, IP, IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    E.coli-derived human NUP133 recombinant protein (Position: Q228-I1156).

    Isotyp

    IgG
  • Applikationshinweise

    Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
    Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human, Rat
    Immunoprecipitation, 0.5-2 μg/mL, Human
    ELISA, 0.1-0.5 μg/mL, -
    1. Belgareh, N., Rabut, G., Bai, S. W., van Overbeek, M., Beaudouin, J., Daigle, N., Zatsepina, O. V., Pasteau, F., Labas, V., Fromont-Racine, M., Ellenberg, J., Doye, V. An evolutionarily conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells. J. Cell. Biol. 154: 1147-1160, 2001. 2. Braun, D. A., Lovric, S., Schapiro, D., Schneider, R., Marquez, J., Asif, M., Hussain, M. S., Daga, A., Widneier, E., Rao, J., Ashraf, S., Tan, W., and 46 others. Mutations in multiple components of the nuclear pore complex cause nephrotic syndrome. J. Clin. Invest. 128: 4313-4328, 2018. 3. Fujita, A., Tsukaguchi, H., Koshimizu, E., Nakazato, H., Itoh, K., Kuraoka, S., Komohara, Y., Shiina, M., Nakamura, S., Kitajima, M., Tsurusaki, Y., Miyatake, S., Ogata, K., Iijima, K., Matsumoto, N., Miyake, N. Homozygous splicing mutation in NUP133 causes Galloway-Mowat syndrome. Ann. Neurol. 84: 814-828, 2018. Note: Erratum: Ann. Neurol. 85: 462-463, 2019.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
  • Target

    NUP133 (Nucleoporin 133kDa (NUP133))

    Andere Bezeichnung

    NUP133

    Hintergrund

    Synonyms: Cytoskeleton-associated protein 5, Colonic and hepatic tumor overexpressed gene protein, Ch-TOG, CKAP5, KIAA0097

    Tissue Specificity: Overexpressed in hepatomas and colonic tumors. Also expressed in skeletal muscle, brain, heart, placenta, lung, liver, kidney and pancreas. Expression is elevated in the brain, highly expressed in the Purkinje cell bodies of the cerebellum.

    Background: Nuclear pore complex protein Nup133, or Nucleoporin Nup133, is a protein that in humans is encoded by the NUP133 gene. The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. The nucleoporin protein encoded by this gene displays evolutionarily conserved interactions with other nucleoporins. This protein, which localizes to both sides of the nuclear pore complex at interphase, remains associated with the complex during mitosis and is targeted at early stages to the reforming nuclear envelope. This protein also localizes to kinetochores of mitotic cells.

    Molekulargewicht

    129 kDa

    Gen-ID

    55746
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