MYO1E Antikörper (AA 221-1065)

Produktnummer ABIN7600705

Der Kaninchen Polyklonal Anti-MYO1E-Antikörper wurde für WB, ELISA und FACS validiert. Er ist geeignet, MYO1E in Proben von Human zu detektieren.

Kurzübersicht für MYO1E Antikörper (AA 221-1065) (ABIN7600705)

Target: MYO1E (Myosin IE (MYO1E))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MYO1E Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Produktdetails anti-MYO1E Antikörper

Bindungsspezifität: AA 221-1065

Verwendungszweck: Anti-MYO1E Antibody Picoband®

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Produktmerkmale: Anti-MYO1E Antibody Picoband® (ABIN7600705). Tested in WB, Flow Cytometry, ELISA applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human MYO1E recombinant protein (Position: A221-Q1065). Human MYO1E shares 95.9% and 95.3% amino acid (aa) sequence identity with mouse and rat MYO1E, respectively.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.25-0.5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL
1. Bement, W. M., Wirth, J. A., Mooseker, M. S. Cloning and mRNA expression of human unconventional myosin-IC: a homologue of amoeboid myosins-I with a single IQ motif and an SH3 domain. J. Molec. Biol. 243: 356-363, 1994. 2. Hasson, T., Skowron, J. F., Gilbert, D. J., Avraham, K. B., Perry, W. L., Bement, W. M., Anderson, B. L., Sherr, E. H., Chen, Z.-Y., Greene, L. A., Ward, D. C., Corey, D. P., Mooseker, M. S., Copeland, N. G., Jenkins, N. A. Mapping of unconventional myosins in mouse and human. Genomics 36: 431-439, 1996. 3. Krendel, M., Kim, S. V., Willinger, T., Wang, T., Kashgarian, M., Flavell, R. A., Mooseker, M. S. Disruption of myosin 1e promotes podocyte injury. J. Am. Soc. Nephrol. 20: 86-94, 2009.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Details zu MYO1E

Target: MYO1E (Myosin IE (MYO1E))

Andere Bezeichnung: MYO1E

Hintergrund:

Synonyms: MYO1E, MYO1C, Unconventional myosin-Ie, Myosin-Ic, Unconventional myosin 1E

Background: This gene encodes a member of the nonmuscle class I myosins which are a subgroup of the unconventional myosin protein family. The unconventional myosin proteins function as actin-based molecular motors. Class I myosins are characterized by a head (motor) domain, a regulatory domain and a either a short or long tail domain. Among the class I myosins, this protein is distinguished by a long tail domain that is involved in crosslinking actin filaments. This protein localizes to the cytoplasm and may be involved in intracellular movement and membrane trafficking. Mutations in this gene are the cause of focal segmental glomerulosclerosis-6. This gene has been referred to as myosin IC in the literature but is distinct from the myosin IC gene located on chromosome 17.

Molekulargewicht: 127 kDa

Gen-ID: 4643

UniProt: Q12965

Pathways: Platelet-derived growth Factor Receptor Signaling