PMVK Antikörper (AA 22-192)

Produktnummer ABIN7600680

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch PMVK in WB und ELISA. Er zeigt eine Reaktivität gegenüber Human und Maus.

Kurzübersicht für PMVK Antikörper (AA 22-192) (ABIN7600680)

Target: PMVK (Phosphomevalonate Kinase (PMVK))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PMVK Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-PMVK Antikörper

Bindungsspezifität: AA 22-192

Verwendungszweck: Anti-PMVK Antibody Picoband®

Produktmerkmale: Anti-PMVK Antibody Picoband® (ABIN7600680). Tested in WB, Flow Cytometry, ELISA applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human PMVK recombinant protein (Position: K22-L192). Human PMVK shares 82.5% amino acid (aa) sequence identity with mouse PMVK.

Anwendungsinformationen

Applikationshinweise: Western blot, 0.25-0.5 μg/mL, Human, Mouse
ELISA, 0.1-0.5 μg/mL, -
1. Chambliss, K. L., Slaughter, C. A., Schreiner, R., Hoffmann, G. F., Gibson, K. M. Molecular cloning of human phosphomevalonate kinase and identification of a consensus peroxisomal targeting sequence. J. Biol. Chem. 271: 17330-17334, 1996. 2. Olivier, L. M., Chambliss, K. L., Gibson, K. M., Krisans, S. K. Characterization of phosphomevalonate kinase: chromosomal localization, regulation, and subcellular targeting. J. Lipid Res. 40: 672-679, 1999. 3. Zhang, Z., Li, C., Wu, F., Ma, R., Luan, J., Yang, F., Liu, W., Wang, L., Zhang, S., Liu, Y., Gu, J., Hua, W., and 13 others. Genomic variations of the mevalonate pathway in porokeratosis. eLife 4: e06322, 2015. Note: Electronic Article. Erratum: eLife 5: e14383, 2016.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Details zu PMVK

Target: PMVK (Phosphomevalonate Kinase (PMVK))

Andere Bezeichnung: PMVK

Hintergrund: This gene encodes a peroxisomal enzyme that is a member of the galactokinase, homoserine kinase, mevalonate kinase, and phosphomevalonate kinase (GHMP) family of ATP-dependent enzymes. The encoded protein catalyzes the conversion of mevalonate 5-phosphate to mevalonate 5-diphosphate, which is the fifth step in the mevalonate pathway of isoprenoid biosynthesis. Mutations in this gene are linked to certain types of porokeratosis including disseminated superficial porokeratosis. Alternative splicing results in multiple transcript variants.

Molekulargewicht: 22 kDa

Gen-ID: 10654

UniProt: Q15126