TMEM52B Antikörper (AA 22-183)

Produktnummer ABIN7600679

Produktdetails anti-TMEM52B Antikörper

Target: TMEM52B (Transmembrane Protein 52B (TMEM52B))

Bindungsspezifität: AA 22-183

Reaktivität: Human, Maus, Ratte, Affe

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TMEM52B Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Flow Cytometry (FACS)

Verwendungszweck: Anti-TMEM52B Antibody Picoband®

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-TMEM52B Antibody Picoband® (ABIN7600679). Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human, Monkey, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human TMEM52B recombinant protein (Position: T22-N183).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.25-0.5 μg/mL, Human, Monkey, Mouse, Rat
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Zhang JX, et al. (2019) A positive feedback loop consisting of c12orf59/nf-κb/cdh11 promotes gastric cancer invasion and metastasis. J Exp Clin Cancer Res 38 (1): 164. 2. Xie J, et al. (2016) Down-regulation of c12orf59 is associated with a poor prognosis and vhl mutations in renal cell carcinoma. Oncotarget 7 (6): 6824-6834. 3. Clark HF, et al. (2003) The secreted protein discovery initiative (spdi), a large-scale effort to identify novel human secreted and transmembrane proteins: A bioinformatics assessment. Genome Res 13 (10): 2265-2270.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Details zu TMEM52B

Target: TMEM52B (Transmembrane Protein 52B (TMEM52B))

Andere Bezeichnung: TMEM52B (TMEM52B Produkte)

Hintergrund:

Synonyms: Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1, PYROXD1

Tissue Specificity: Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.

Background: TMEM52B (Transmembrane Protein 52B, also known as C12orf59) is a Protein Coding gene. The TMEM52B gene, located on 12p13.2, is conserved in chimpanzee, dog, cow, mouse, rat, chicken, and frog. 2 alternatively spliced human isoforms have been reported. The 183-amino acid protein has a reported mass of 20,002 daltons. The cellular localization is predicted to be membrane-associated. C12orf59 might act as a potential oncogenic protein in gastric cancer (GC). Researchers propose that the decreased C12orf59 expression status is a prognostic biomarker of ccRCC and cooperates with the loss of von Hippel-Lindau (VHL) all the while promoting renal carcinogenesis. 192 organisms have orthologs with human gene TMEM52B.

Molekulargewicht: 24 kDa

Gen-ID: 120939