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TMEM52B Antikörper (AA 22-183)

Dieses Anti-TMEM52B-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von TMEM52B in ELISA, WB und FACS. Geeignet für Human, Maus, Ratte und Affe.
Produktnummer ABIN7600679

Kurzübersicht für TMEM52B Antikörper (AA 22-183) (ABIN7600679)

Target

TMEM52B (Transmembrane Protein 52B (TMEM52B))

Reaktivität

  • 6
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Human, Maus, Ratte, Affe

Wirt

  • 6
Kaninchen

Klonalität

  • 6
Polyklonal

Konjugat

  • 2
  • 2
  • 1
  • 1
Dieser TMEM52B Antikörper ist unkonjugiert

Applikation

ELISA, Western Blotting (WB), Flow Cytometry (FACS)
  • Bindungsspezifität

    • 5
    • 1
    AA 22-183

    Verwendungszweck

    Anti-TMEM52B Antibody Picoband®

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins.

    Produktmerkmale

    Anti-TMEM52B Antibody Picoband® (ABIN7600679). Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human, Monkey, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    E.coli-derived human TMEM52B recombinant protein (Position: T22-N183).

    Isotyp

    IgG
  • Applikationshinweise

    Western blot, 0.25-0.5 μg/mL, Human, Monkey, Mouse, Rat
    Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
    ELISA, 0.1-0.5 μg/mL, -
    1. Zhang JX, et al. (2019) A positive feedback loop consisting of c12orf59/nf-κb/cdh11 promotes gastric cancer invasion and metastasis. J Exp Clin Cancer Res 38 (1): 164. 2. Xie J, et al. (2016) Down-regulation of c12orf59 is associated with a poor prognosis and vhl mutations in renal cell carcinoma. Oncotarget 7 (6): 6824-6834. 3. Clark HF, et al. (2003) The secreted protein discovery initiative (spdi), a large-scale effort to identify novel human secreted and transmembrane proteins: A bioinformatics assessment. Genome Res 13 (10): 2265-2270.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
  • Target

    TMEM52B (Transmembrane Protein 52B (TMEM52B))

    Andere Bezeichnung

    TMEM52B

    Hintergrund

    Synonyms: Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1, PYROXD1

    Tissue Specificity: Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.

    Background: TMEM52B (Transmembrane Protein 52B, also known as C12orf59) is a Protein Coding gene. The TMEM52B gene, located on 12p13.2, is conserved in chimpanzee, dog, cow, mouse, rat, chicken, and frog. 2 alternatively spliced human isoforms have been reported. The 183-amino acid protein has a reported mass of 20,002 daltons. The cellular localization is predicted to be membrane-associated. C12orf59 might act as a potential oncogenic protein in gastric cancer (GC). Researchers propose that the decreased C12orf59 expression status is a prognostic biomarker of ccRCC and cooperates with the loss of von Hippel-Lindau (VHL) all the while promoting renal carcinogenesis. 192 organisms have orthologs with human gene TMEM52B.

    Molekulargewicht

    24 kDa

    Gen-ID

    120939
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