OAT Antikörper (AA 214-439)

Produktnummer ABIN7600649

Dieses Anti-OAT-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von OAT in WB, ELISA, IHC und FACS. Geeignet für Human, Maus und Ratte.

Kurzübersicht für OAT Antikörper (AA 214-439) (ABIN7600649)

Target: OAT (Ornithine Aminotransferase (OAT))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser OAT Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Produktdetails anti-OAT Antikörper

Bindungsspezifität: AA 214-439

Verwendungszweck: Anti-ornithine aminotransferase/OAT Antibody Picoband®

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-ornithine aminotransferase/OAT Antibody Picoband® (ABIN7600649). Tested in ELISA, Flow Cytometry, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human OAT recombinant protein (Position: A214-F439).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.1-0.25 μg/mL, Human, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Akaki, Y., Hotta, Y., Mashima, Y., Murakami, A., Kennaway, N. G., Weleber, R. G., Inana, G. A deletion in the ornithine aminotransferase gene in gyrate atrophy. J. Biol. Chem. 267: 12950-12954, 1992. 2. Barrett, D. J., Bateman, J. B., Sparkes, R. S., Mohandas, T., Klisak, I., Inana, G. Chromosomal localization of human ornithine aminotransferase gene sequences to 10q26 and Xp11.2. Invest. Ophthal. Vis. Sci. 28: 1037-1042, 1987. 3. Bisaillon, J. J., Radden, L. A., II, Szabo, E. T., Hughes, S. R., Feliciano, A. M., Nesta, A. V., Petrovic, B., Palanza, K. M., Lancinskas, D., Szmurlo, T. A., Artus, D. C., Kapper, M. A., Mulrooney, J. P., King, T. R. The retarded hair growth (rhg) mutation in mice is an allele of ornithine aminotransferase (Oat). Molec. Genet. Metab. Rep. 1: 378-390, 2014.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Details zu OAT

Target: OAT (Ornithine Aminotransferase (OAT))

Andere Bezeichnung: OAT

Hintergrund:

Synonyms: Podoplanin, Aggrus, Glycoprotein 36, Gp36, PA2.26 antigen, T1-alpha, T1A, 29 kDa cytosolic podoplanin intracellular domain, PICD, PDPN, GP36, PSEC0003, PSEC0025

Tissue Specificity: Highly expressed in placenta, lung, skeletal muscle and brain. Weakly expressed in brain, kidney and liver. In placenta, expressed on the apical plasma membrane of endothelium. In lung, expressed in alveolar epithelium. Up-regulated in colorectal tumors and expressed in 25 % of early oral squamous cell carcinomas.

Background: Ornithine aminotransferase (OAT) is an enzyme which is encoded in human by the OAT gene located on chromosome 10. This gene encodes the mitochondrial enzyme ornithine aminotransferase, which is a key enzyme in the pathway that converts arginine and ornithine into the major excitatory and inhibitory neurotransmitters glutamate and GABA. Mutations that result in a deficiency of this enzyme cause the autosomal recessive eye disease Gyrate Atrophy. Alternatively spliced transcript variants encoding different isoforms have been described. Related pseudogenes have been defined on the X chromosome.

Molekulargewicht: 49 kDa

Gen-ID: 4942

UniProt: P04181