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ENDOU Antikörper (AA 20-386)

Der Kaninchen Polyklonal Anti-ENDOU-Antikörper wurde für WB, ELISA, IHC, FACS, ICC und IF validiert. Er ist geeignet, ENDOU in Proben von Human zu detektieren.
Produktnummer ABIN7600552

Kurzübersicht für ENDOU Antikörper (AA 20-386) (ABIN7600552)

Target

Alle ENDOU Antikörper anzeigen
ENDOU (Endonuclease, PolyU-Specific (ENDOU))

Reaktivität

  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Human

Wirt

  • 2
  • 1
Kaninchen

Klonalität

  • 2
  • 1
Polyklonal

Konjugat

  • 3
Dieser ENDOU Antikörper ist unkonjugiert

Applikation

Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunofluorescence (IF)
  • Bindungsspezifität

    • 1
    • 1
    AA 20-386

    Verwendungszweck

    Anti-PP11/ENDOU Antibody Picoband®

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins.

    Produktmerkmale

    Anti-PP11/ENDOU Antibody Picoband® (ABIN7600552). Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    E.coli-derived human PP11/ENDOU recombinant protein (Position: K20-T386).

    Isotyp

    IgG
  • Applikationshinweise

    Western blot, 0.25-0.5 μg/mL, Human
    Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human
    Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
    Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
    ELISA, 0.1-0.5 μg/mL, -
    1. Gross, M. B. Personal Communication. Baltimore, Md. 2/24/2014. 2. Grundmann, U., Romisch, J., Siebold, B., Bohn, H., Amann, E. Cloning and expression of a cDNA encoding human placental protein 11, a putative serine protease with diagnostic significance as a tumor marker. DNA Cell Biol. 9: 243-250, 1990. 3. Laneve, P., Gioia, U., Ragno, R., Altieri, F., Di Franco, C., Santini, T., Arceci, M., Bozzoni, I., Caffarelli, E. The tumor marker human placental protein 11 is an endoribonuclease. J. Biol. Chem. 283: 34712-34719, 2008.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
  • Target

    ENDOU (Endonuclease, PolyU-Specific (ENDOU))

    Andere Bezeichnung

    ENDOU

    Hintergrund

    Synonyms: Mesoderm posterior protein 1, Class C basic helix-loop-helix protein 5, bHLHc5, MESP1, BHLHC5

    Tissue Specificity: Highly expressed in brain and weakly in heart, small intestine and uterus. Isoform 1A is mostly expressed in granular cell and molecular layer. Isoform 1B is mostly expressed in Purkinje cells. Isoform 1E is predominantly expressed in peripheral tissues as kidney, lung, trachea, colon, small intestine, stomach, bone marrow, thymus and mammary gland. .

    Background: Endonuclease, poly(U) specific is a protein that in humans is encoded by the ENDOU gene. This gene encodes a protein with endoribonuclease activity that binds polyuridine-enriched single-stranded RNA. This gene was initially characterized based on its high expression in placenta but was mischaracterized as a serine protease. In mouse, this gene promotes tolerance to self-antigens by regulating B cell activation-induced cell death (AICD). The protein may be useful as a tumor marker. Multiple alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene.

    Molekulargewicht

    47 kDa

    Gen-ID

    8909

    UniProt

    P21128
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