2B4 Antikörper (AA 20-374)

Produktnummer ABIN7600551

Dieser Kaninchen Polyklonal Antikörper erkennt spezifisch 2B4 in WB, ELISA und IHC. Er zeigt eine Reaktivität gegenüber Maus und Ratte.

Kurzübersicht für 2B4 Antikörper (AA 20-374) (ABIN7600551)

Target: 2B4 (CD244) (Natural Killer Cell Receptor 2B4 (CD244))

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser 2B4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-2B4 Antikörper

Bindungsspezifität: AA 20-374

Verwendungszweck: Anti-2B4/Cd244 Antibody

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-2B4/Cd244 Antibody (ABIN7600551). Tested in ELISA, WB applications. This antibody reacts with Mouse. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived mouse 2B4/Cd244 recombinant protein (Position: Q20-N374).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.25-0.5 μg/mL, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Mouse
ELISA, 0.1-0.5 μg/mL, -

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Details zu 2B4

Target: 2B4 (CD244) (Natural Killer Cell Receptor 2B4 (CD244))

Andere Bezeichnung: Cd244

Hintergrund:

Synonyms: Natural killer cell receptor 2B4, NK cell type I receptor protein 2B4, NKR2B4, Non-MHC restricted killing associated, SLAM family, SLAMF4, Signaling lymphocytic activation molecule 4, CD244, Cd244, 2b4, Nmrk

Tissue Specificity: Expressed in natural killer (NK) cells, T cells and dendritic cells.

Background: CD244 (Cluster of Differentiation 244) is a human protein encoded by the CD244 gene. It is also known as Natural Killer Cell Receptor 2B4. Tangye et al. (1999) mapped the 2B4 gene to 1q22. Suzuki et al. (2008) identified a functional single-nucleotide polymorphism (SNP) in the CD244 gene that contributes to rheumatoid arthritis susceptibility. Functional analysis by Boles et al. (1999) demonstrated that engagement of 2B4 with specific antibody activates NK cytolytic activity. Using recombinant human NK cell-activating ligand 2B4 fused to domains 3 and 4 of rodent Cd4 and flow cytometric analysis, Brown et al. (1998) demonstrated that CD48 binds to 2B4. Watzl et al. (2000) showed that antibody-mediated cross-linking of 2B4 leads to its rapid tyrosine phosphorylation, which is necessary for 2B4-mediated killer cell activity.

Molekulargewicht: 65-75 kDa

Gen-ID: 102927459

UniProt: Q07763