TUBB1 Antikörper (AA 18-435)

Produktnummer ABIN7600343

Dieses Anti-TUBB1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von TUBB1 in WB, ELISA, IHC, IF, ICC und FACS. Geeignet für Human, Maus und Ratte.

Kurzübersicht für TUBB1 Antikörper (AA 18-435) (ABIN7600343)

Target: TUBB1 (Tubulin, beta 1 (TUBB1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TUBB1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Produktdetails anti-TUBB1 Antikörper

Bindungsspezifität: AA 18-435

Verwendungszweck: Anti-Tubulin beta Antibody Picoband®

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-Tubulin beta Antibody Picoband® (ABIN7600343). Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human Tubulin beta recombinant protein (Position: A18-D435).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Davis, B., Toivio-Kinnucan, M., Schuller, S., Boudreaux, M. K. Mutation in beta-1-tubulin correlates with macrothrombocytopenia in Cavalier King Charles Spaniels. J. Vet. Intern. Med. 22: 540-545, 2008. 2. Freson, K., De Vos, R., Wittevrongel, C., Thys, C., Defoor, J., Vanhees, L., Vermylen, J., Peerlinck, K., Van Geet, C. The TUBB1 Q43P functional polymorphism reduces the risk of cardiovascular disease in men by modulating platelet function and structure. Blood 106: 2356-2362, 2005. 3. Kunishima, S., Kobayashi, R., Itoh, T. J., Hamaguchi, M., Saito, H. Mutation of the beta-1-tubulin gene associated with congenital macrothrombocytopenia affecting microtubule assembly. Blood 113: 458-461, 2009.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Details zu TUBB1

Target: TUBB1 (Tubulin, beta 1 (TUBB1))

Andere Bezeichnung: TUBB1

Hintergrund:

Synonyms: RNA binding protein fox-1 homolog 2, Fox-1 homolog B, Hexaribonucleotide-binding protein 2, RNA-binding motif protein 9, RNA-binding protein 9, Repressor of tamoxifen transcriptional activity, RBFOX2, FOX2, HRNBP2, RBM9, RTA

Tissue Specificity: Expressed in fetal brain. Highly expressed in brain and placenta. Lower levels in heart, liver, thymus, kidney and lung. Located to endothelial cells and neuronal cells of the suprachiasmatic nucleus (SCN). Also detected in endothelial cells of the heart, lung and kidney. In the brain, specifically expressed in the thalamus, hippocampus and amygdala.

Background: TUBB1 is a gene that codes for the protein Tubulin beta-1 chain in humans. This gene encodes a member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is specifically expressed in platelets and megakaryocytes and may be involved in proplatelet production and platelet release. A mutations in this gene is associated with autosomal dominant macrothrombocytopenia. Two pseudogenes of this gene are found on chromosome Y.

Molekulargewicht: 55 kDa

Gen-ID: 81027

UniProt: Q9H4B7

Pathways: Microtubule Dynamics