ADRB3 Antikörper (AA 179-250)

Produktnummer ABIN7600307

Dieses Anti-ADRB3-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von ADRB3 in WB, ELISA, IF und ICC. Geeignet für Human, Ratte und Maus.

Kurzübersicht für ADRB3 Antikörper (AA 179-250) (ABIN7600307)

Target: ADRB3 (Adrenergic, beta-3-, Receptor (ADRB3))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ADRB3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Produktdetails anti-ADRB3 Antikörper

Bindungsspezifität: AA 179-250

Verwendungszweck: Anti-beta 3 Adrenergic Receptor/ADRB3 Antibody Picoband®

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-beta 3 Adrenergic Receptor/ADRB3 Antibody Picoband® (ABIN7600307). Tested in ELISA, IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human beta 3 Adrenergic Receptor/ADRB3 recombinant protein (Position: R179-S250).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
Immunocytochemistry/Immunofluorescence, 2 μg/mL, Human
ELISA, 0.1-0.5 μg/mL, -
1. Bachman, E. S., Dhillon, H., Zhang, C.-Y., Cinti, S., Bianco, A. C., Kobilka, B. K., Lowell, B. B. Beta-AR signaling required for diet-induced thermogenesis and obesity resistance. Science 297: 843-845, 2002. 2. Buettner, R., Schaffler, A., Arndt, H., Rogler, G., Nusser, J., Zietz, B., Enger, I., Hugl, S., Cuk, A., Scholmerich, J., Palitzsch, K.-D. The trp64arg polymorphism of the beta-3-adrenergic receptor gene is not associated with obesity or type 2 diabetes mellitus in a large population-based Caucasian cohort. J. Clin. Endocr. Metab. 83: 2892-2897, 1998. 3. Cagliani, R., Fumagalli, M., Pozzoli, U., Riva, S., Comi, G. P., Torri, F., Macciardi, F., Bresolin, N., Sironi, M. Diverse evolutionary histories for beta-adrenoreceptor genes in humans. Am. J. Hum. Genet. 85: 64-75, 2009.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na₂HPO₄, 0.01 mg NaN₃.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Details zu ADRB3

Target: ADRB3 (Adrenergic, beta-3-, Receptor (ADRB3))

Andere Bezeichnung: ADRB3

Hintergrund:

Synonyms: Beta-3 adrenergic receptor, Beta-3 adrenoreceptor, Beta-3 adrenoceptor, ADRB3, ADRB3R, B3AR

Tissue Specificity: Expressed mainly in adipose tissues.

Background: The beta-3 adrenergic receptor (β3 adrenoreceptor), also known as ADRB3, is a beta-adrenergic receptor, and also denotes the human gene encoding it. It is mapped to 8p11.23. The protein encoded by this gene belongs to the family of beta adrenergic receptors, which mediate catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor is located mainly in the adipose tissue and is involved in the regulation of lipolysis and thermogenesis. Obesity and bodyweight-related disorders are correlated with certain polymorphisms in three subtypes of beta-adrenoceptor, among them, the ADRB3 gene.

Molekulargewicht: 44 kDa

Gen-ID: 155

UniProt: P13945

Pathways: cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Feeding Behaviour, Brown Fat Cell Differentiation