SNIP1 Antikörper (AA 16-372)

Produktnummer ABIN7600177

Dieses Anti-SNIP1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von SNIP1 in WB, ELISA und FACS. Geeignet für Human.

Kurzübersicht für SNIP1 Antikörper (AA 16-372) (ABIN7600177)

Target: SNIP1 (Smad Nuclear Interacting Protein 1 (SNIP1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SNIP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Produktdetails anti-SNIP1 Antikörper

Bindungsspezifität: AA 16-372

Verwendungszweck: Anti-SNIP1 Antibody Picoband®

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-SNIP1 Antibody Picoband® (ABIN7600177). Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human SNIP1 recombinant protein (Position: H16-E372).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.25-0.5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Fujii, M., Lyakh, L. A., Bracken, C. P., Fukuoka, J., Hayakawa, M., Tsukiyama, T., Soll, S. J., Harris, M., Rocha, S., Roche, K. C., Tominaga, S., Jen, J., Perkins, N. D., Lechleider, R. J., Roberts, A. B. SNIP1 is a candidate modifier of the transcriptional activity of c-Myc on E box-dependent target genes. Molec. Cell 24: 771-783, 2006. 2. Gross, M. B. Personal Communication. Baltimore, Md. 6/8/2017. 3. Kim, R. H., Flanders, K. C., Reffey, S. B., Anderson, L. A., Duckett, C. S., Perkins, N. D., Roberts, A. B. SNIP1 inhibits NF-kappa-B signaling by competing for its binding to the C/H1 domain of CBP/p300 transcriptional co-activators. J. Biol. Chem. 276: 46297-46304, 2001.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Details zu SNIP1

Target: SNIP1 (Smad Nuclear Interacting Protein 1 (SNIP1))

Andere Bezeichnung: SNIP1

Hintergrund:

Synonyms: Tetraspanin-12, Tspan-12, Tetraspan NET-2, Transmembrane 4 superfamily member 12, TSPAN12, NET2, TM4SF12, UNQ774/PRO1568

Tissue Specificity: Expressed in testis, in Sertoli cells, ejaculated spermatozoa and in seminal fluid (at protein level).

Background: Smad nuclear-interacting protein 1 is a protein that in humans is encoded by the SNIP1 gene. This gene encodes a protein that contains a coiled-coil motif and C-terminal forkhead-associated (FHA) domain. The encoded protein functions as a transcriptional coactivator that increases c-Myc activity and inhibits transforming growth factor beta (TGF-beta) and nuclear factor kappa-B (NF-kB) signaling. The encoded protein also regulates the stability of cyclin D1 mRNA, and may play a role in cell proliferation and cancer progression. Mutations in this gene are a cause of psychomotor retardation, epilepsy, and craniofacial dysmorphism (PMRED).

Molekulargewicht: 46 kDa

Gen-ID: 79753

Pathways: SARS-CoV-2 Protein Interaktom, Phosphorylierungen bei SARS-CoV-2 Infektion