TBR1 Antikörper (AA 15-682)

Produktnummer ABIN7600119

Der Kaninchen Polyklonal Anti-TBR1-Antikörper wurde für WB, ELISA, IHC und FACS validiert. Er ist geeignet, TBR1 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für TBR1 Antikörper (AA 15-682) (ABIN7600119)

Target: TBR1 (T-Box Brain Gene 1 (TBR1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TBR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Produktdetails anti-TBR1 Antikörper

Bindungsspezifität: AA 15-682

Verwendungszweck: Anti-TBR1 Antibody Picoband®

Produktmerkmale: Anti-TBR1 Antibody Picoband® (ABIN7600119). Tested in WB, Flow Cytometry, ELISA applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human TBR1 recombinant protein (Position: K15-S682). Human TBR1 shares 99.3% amino acid (aa) sequence identity with mouse TBR1.

Anwendungsinformationen

Applikationshinweise: Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
Immunohistochemistry, 2-5 μg/mL, Mouse
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Bulfone, A., Smiga, S. M., Shimamura, K., Peterson, A., Puelles, L., Rubenstein, J. L. R. T-brain-1: a homolog of Brachyury whose expression defines molecularly distinct domains within the cerebral cortex. Neuron 15: 63-78, 1995. 2. den Hoed, J., Sollis, E., Venselaar, H., Estruch, S. B., Deriziotis, P., Fisher, S. E. Functional characterization of TBR1 variants in neurodevelopmental disorder. Sci. Rep. 8: 14279, 2018. 3. Deriziotis, P., O'Roak, B. J., Graham, S. A., Estruch, S. B., Dimitropoulou, D., Bernier, R. A., Gerdts, J., Shendure, J., Eichler, E. E., Fisher, S. E. De novo TBR1 mutations in sporadic autism disrupt protein functions. Nature Commun. 5: 4954, 2014. Note: Electronic Article.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Details zu TBR1

Target: TBR1 (T-Box Brain Gene 1 (TBR1))

Andere Bezeichnung: TBR1

Hintergrund: T-box, brain, 1 is a transcription factor protein important in vertebrate embryo development. It is encoded by the TBR1 gene. This gene is a member of a conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of numerous developmental processes. In mouse, the ortholog of this gene is expressed in the cerebral cortex, hippocampus, amygdala and olfactory bulb and is thought to play an important role in neuronal migration and axonal projection. In mouse, the C-terminal region of this protein was found to be necessary and sufficient for association with the guanylate kinase domain of calcium/calmodulin-dependent serine protein kinase.

Molekulargewicht: 74 kDa

Gen-ID: 10716

UniProt: Q16650