Cadherin 13 Antikörper (AA 149-692)

Produktnummer ABIN7600095

Der Kaninchen Polyklonal Anti-Cadherin 13-Antikörper wurde für WB, IHC, ELISA, ICC, FACS und IF validiert. Er ist geeignet, Cadherin 13 in Proben von Human und Ratte zu detektieren.

Kurzübersicht für Cadherin 13 Antikörper (AA 149-692) (ABIN7600095)

Target: Cadherin 13 (CDH13)

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Cadherin 13 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC), Flow Cytometry (FACS), Immunofluorescence (IF)

Produktdetails anti-Cadherin 13 Antikörper

Bindungsspezifität: AA 149-692

Verwendungszweck: Anti-H Cadherin/CDH13 Antibody Picoband®

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-H Cadherin/CDH13 Antibody Picoband® (ABIN7600095). Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human H Cadherin/CDH13 recombinant protein (Position: E149-A692).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.25-0.5 μg/mL, Human
Immunohistochemistry (Paraffin-embedded Section), 1-2 μg/mL, Human, Rat
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Kremmidiotis, G., Baker, E., Crawford, J., Eyre, H. J., Nahmias, J., Callen, D. F. Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity. Genomics 49: 467-471, 1998. 2. Lee, S. W. H-cadherin, a novel cadherin with growth inhibitory functions and diminished expression in human breast cancer. Nature Med. 2: 776-782, 1996. 3. Sato, M., Mori, Y., Sakurada, A., Fujimura, S., Horii, A. The H-cadherin (CDH13) gene is inactivated in human lung cancer. Hum. Genet. 103: 96-101, 1998. Note: Erratum: Hum. Genet. 103: 532 only, 1998.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Details zu Cadherin 13

Target: Cadherin 13 (CDH13)

Andere Bezeichnung: CDH13

Hintergrund:

Synonyms: Neuronal acetylcholine receptor subunit alpha-3, CHRNA3, NACHRA3

Background: T-cadherin also known as cadherin 13, H-cadherin (heart) (CDH13) is a unique member of cadherin superfamily because it lacks the transmembrane and cytoplasmic domains and is anchored to the cells membrane through the GPI anchor. This protein acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. The gene is hypermethylated in many types of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.

Molekulargewicht: 105 kDa, 130 kDa

Gen-ID: 1012

UniProt: P55290

Pathways: EGFR Signaling Pathway, Cell-Cell Junction Organization