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RHBDF2 Antikörper (AA 145-529)

Dieses Anti-RHBDF2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von RHBDF2 in ELISA, WB und FACS. Geeignet für Human.
Produktnummer ABIN7600069

Kurzübersicht für RHBDF2 Antikörper (AA 145-529) (ABIN7600069)

Target

Alle RHBDF2 Antikörper anzeigen
RHBDF2 (Rhomboid 5 Homolog 2 (RHBDF2))

Reaktivität

  • 18
  • 2
Human

Wirt

  • 18
Kaninchen

Klonalität

  • 18
Polyklonal

Konjugat

  • 9
  • 3
  • 2
  • 2
  • 1
  • 1
Dieser RHBDF2 Antikörper ist unkonjugiert

Applikation

  • 13
  • 13
  • 12
  • 2
  • 2
  • 1
ELISA, Western Blotting (WB), Flow Cytometry (FACS)
  • Bindungsspezifität

    • 9
    • 5
    • 5
    • 2
    • 2
    AA 145-529

    Verwendungszweck

    Anti-RHBDF2 Antibody Picoband®

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins.

    Produktmerkmale

    Anti-RHBDF2 Antibody Picoband® (ABIN7600069). Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    E.coli-derived human RHBDF2 recombinant protein (Position: H145-D529).

    Isotyp

    IgG
  • Applikationshinweise

    Western blot, 0.25-0.5 μg/mL, Human
    Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
    ELISA, 0.1-0.5 μg/mL, -
    1. Adrain, C., Zettl, M., Cristova, Y., Taylor, N., Freeman, M. Tumor necrosis factor signaling requires iRhom2 to promote trafficking and activation of TACE. Science 335: 225-228, 2012. 2. Blaydon, D. C., Etheridge, S. L., Risk, J. M., Hennies, H.-C., Gay, L. J., Carroll, R., Plagnol, V., McRonald, F. E., Stevens, H. P., Spurr, N. K., Bishop, D. T., Ellis, A., Jankowski, J., Field, J. K., Leigh, I. M., South, A. P., Kelsell, D. P. RHBDF2 mutations are associated with tylosis, a familial esophageal cancer syndrome. Am. J. Hum. Genet. 90: 340-346, 2012. 3. Brooke, M. A., Etheridge, S. L., Kaplan, N., Simpson, C., O'Toole, E. A., Ishida-Yamamoto, A., Marches, O., Getsios, S., Kelsell, D. P. iRHOM2-dependent regulation of ADAM17 in cutaneous disease and epidermal barrier function. Hum. Molec. Genet. 23: 4064-4076, 2014.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
  • Target

    RHBDF2 (Rhomboid 5 Homolog 2 (RHBDF2))

    Andere Bezeichnung

    RHBDF2

    Hintergrund

    Synonyms: Chromaffin granule amine transporter, Solute carrier family 18 member 1, Vesicular amine transporter 1, VAT1, SLC18A1, VAT1, VMAT1

    Tissue Specificity: Highly expressed in chromaffin cells of the adrenal medulla (at protein level). Detected in peripheral sympathetic ganglia (at protein level). Found in some paracrine cells in stomach and duodenum (at protein level).

    Background: Rhomboid family member 2 is a protein that in humans is encoded by the RHBDF2 gene. Predicted to enable protein transporter activity. Predicted to be involved in negative regulation of protein secretion and regulation of epidermal growth factor receptor signaling pathway. Located in plasma membrane. Implicated in palmoplantar keratoderma-esophageal carcinoma syndrome.

    Molekulargewicht

    97 kDa

    Gen-ID

    79651

    Pathways

    Growth Factor Binding
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