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Espin Antikörper (AA 143-854)

Dieses Anti-Espin-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Espin in WB und ELISA. Geeignet für Maus und Ratte.
Produktnummer ABIN7600060

Kurzübersicht für Espin Antikörper (AA 143-854) (ABIN7600060)

Target

Alle Espin (ESPN) Antikörper anzeigen
Espin (ESPN)

Reaktivität

  • 22
  • 10
  • 10
  • 1
Maus, Ratte

Wirt

  • 21
  • 1
Kaninchen

Klonalität

  • 21
  • 1
Polyklonal

Konjugat

  • 10
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser Espin Antikörper ist unkonjugiert

Applikation

  • 14
  • 10
  • 3
  • 2
  • 2
  • 1
  • 1
Western Blotting (WB), ELISA
  • Bindungsspezifität

    • 8
    • 3
    • 1
    • 1
    AA 143-854

    Verwendungszweck

    Anti-ESPN Antibody Picoband®

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins

    Produktmerkmale

    Anti-ESPN Antibody Picoband® (ABIN7600060). Tested in WB, ELISA applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    E.coli-derived human ESPN recombinant protein (Position: H143-Y854). Human ESPN shares 75.6% and 78.1% amino acid (aa) sequence identity with mouse and rat ESPN, respectively.

    Isotyp

    IgG
  • Applikationshinweise

    Western blot, 0.25-0.5 μg/mL, Mouse, Rat
    ELISA, 0.1-0.5 μg/mL
    1. Ahmed, Z. M., Jaworek, T., Sarangdhar, G. N., Zheng, L., Gul, K., Khan, S. N., Friedman, T. B., Sisk, R. A., Bartles, J. R., Riazuddin, S., Riazuddin, S. Inframe deletion of human ESPN is associated with deafness, vestibulopathy and vision impairment. J. Med. Genet. 55: 479-488, 2018. 2. Bartles, J. R., Wierda, A., Zheng, L. Identification and characterization of espin, an actin-binding protein localized to the F-actin-rich junctional plaques of Sertoli cell ectoplasmic specializations. J. Cell Sci. 109: 1229-1239, 1996. 3. Bartles, J. R., Zheng, L., Li, A., Wierda, A., Chen, B. Small espin: a third actin-bundling protein and potential forked protein ortholog in brush border microvilli. J. Cell Biol. 143: 107-119, 1998.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
  • Target

    Espin (ESPN)

    Andere Bezeichnung

    ESPN

    Hintergrund

    Synonyms: ESPN, DFNB36, LP2654, Espin, Autosomal recessive deafness type 36 protein, Ectoplasmic specialization protein

    Background: This gene encodes a multifunctional actin-bundling protein. It plays a major role in regulating the organization, dimensions, dynamics, and signaling capacities of the actin filament-rich, microvillus-type specializations that mediate sensory transduction in various mechanosensory and chemosensory cells. Mutations in this gene are associated with autosomal recessive neurosensory deafness, and autosomal dominant sensorineural deafness without vestibular involvement.

    Molekulargewicht

    110 kDa

    Gen-ID

    83715

    Pathways

    Sensory Perception of Sound
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