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PAWR Antikörper (AA 13-333)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch PAWR in WB, IHC, ELISA, IF, ICC und FACS. Er zeigt eine Reaktivität gegenüber Maus und Ratte.
Produktnummer ABIN7599938

Kurzübersicht für PAWR Antikörper (AA 13-333) (ABIN7599938)

Target

Alle PAWR Antikörper anzeigen
PAWR (PRKC, Apoptosis, WT1, Regulator (PAWR))

Reaktivität

  • 34
  • 20
  • 20
  • 5
  • 3
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
Maus, Ratte

Wirt

  • 33
  • 1
Kaninchen

Klonalität

  • 32
  • 2
Polyklonal

Konjugat

  • 20
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
Dieser PAWR Antikörper ist unkonjugiert

Applikation

  • 19
  • 13
  • 7
  • 5
  • 3
  • 3
  • 2
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC), Flow Cytometry (FACS)
  • Bindungsspezifität

    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 13-333

    Verwendungszweck

    Anti-PAR4/Pawr Antibody Picoband®

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins.

    Produktmerkmale

    Anti-PAR4/Pawr Antibody Picoband® (ABIN7599938). Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    E.coli-derived mouse PAR4/Pawr recombinant protein (Position: T13-R333).

    Isotyp

    IgG
  • Applikationshinweise

    Western blot, 0.1-0.25 μg/mL, Mouse, Rat
    Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Mouse, Rat
    Immunocytochemistry/Immunofluorescence, 5 μg/mL, Mouse
    Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Mouse
    ELISA, 0.1-0.5 μg/mL, -
    1. Donninger, H., Hesson, L., Vos, M., Beebe, K., Gordon, L., Sidransky, D., Liu, J. W., Schlegel, T., Payne, S., Hartmann, A., Latif, F., Clark, G. J. The Ras effector RASSF2 controls the PAR-4 tumor suppressor. Molec. Cell. Biol. 30: 2608-2620, 2010. 2. Duan, W., Zhang, Z., Gash, D. M., Mattson, M. P. Participation of prostate apoptosis response-4 in degeneration of dopaminergic neurons in models of Parkinson's disease. Ann. Neurol. 46: 587-597, 1999. 3. Johnstone, R. W., See, R. H., Sells, S. F., Wang, J., Muthukkumar, S., Englert, C., Haber, D. A., Licht, J. D., Sugrue, S. P., Roberts, T., Rangnekar, V. M., Shi, Y. A novel repressor, par-4, modulates transcription and growth suppression functions of the Wilms' tumor suppressor WT1. Molec. Cell. Biol. 16: 6945-6956, 1996.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.01 mg Sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Target

    PAWR (PRKC, Apoptosis, WT1, Regulator (PAWR))

    Andere Bezeichnung

    Pawr

    Hintergrund

    Synonyms: Protein ERGIC-53, ER-Golgi intermediate compartment 53 kDa protein, Gp58, Intracellular mannose-specific lectin MR60, Lectin mannose-binding 1, LMAN1, ERGIC53, F5F8D

    Tissue Specificity: Ubiquitous.

    Background: PRKC, apoptosis, WT1, regulator, also known as PAWR or Prostate apoptosis response-4 (Par-4), is a human gene. This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms. The intracellular mechanism involves the inhibition of pro-survival pathways and the activation of Fas-mediated apoptosis, while the extracellular mechanism involves the binding of a secreted form of this protein to glucose regulated protein 78 (GRP78) on the cell surface, which leads to activation of the extrinsic apoptotic pathway. This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated different tumors. The encoded protein also plays an important role in the progression of age-related diseases.

    Molekulargewicht

    45 kDa

    Gen-ID

    114774

    UniProt

    Q925B0
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