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RYR2 Antikörper (AA 1293-1423)

Der Kaninchen Polyklonal Anti-RYR2-Antikörper wurde für ELISA, IHC und WB validiert. Er ist geeignet, RYR2 in Proben von Human zu detektieren.
Produktnummer ABIN7599921

Kurzübersicht für RYR2 Antikörper (AA 1293-1423) (ABIN7599921)

Target

Alle RYR2 Antikörper anzeigen
RYR2 (Ryanodine Receptor 2 (Cardiac) (RYR2))

Reaktivität

  • 32
  • 19
  • 19
  • 3
Human

Wirt

  • 30
  • 2
Kaninchen

Klonalität

  • 30
  • 2
Polyklonal

Konjugat

  • 21
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser RYR2 Antikörper ist unkonjugiert

Applikation

  • 14
  • 14
  • 13
  • 10
  • 6
  • 5
  • 5
  • 2
  • 2
ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
  • Bindungsspezifität

    • 13
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1293-1423

    Verwendungszweck

    Anti-RYR2 Antibody Picoband®

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins.

    Produktmerkmale

    Anti-RYR2 Antibody Picoband® (ABIN7599921). Tested in ELISA, IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    E.coli-derived human RYR2 recombinant protein (Position: Q1293-T1423).

    Isotyp

    IgG
  • Applikationshinweise

    Western blot, 0.25-0.5 μg/mL, Human
    Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human
    ELISA, 0.1-0.5 μg/mL, -
    1. Benkusky, N. A., Farrell, E. F., Valdivia, H. H. Ryanodine receptor channelopathies. Biochem. Biophys. Res. Commun. 322: 1280-1285, 2004. 2. Bhuiyan, Z. A., van den Berg, M. P., van Tintelen, J. P., Bink-Boelkens, M. T. E., Wiesfeld, A. C. P., Alders, M., Postma, A. V., van Langen, I., Mannens, M. M. A. M., Wilde, A. A. M. Expanding spectrum of human RYR2-related disease: new electrocardiographic, structural, and genetic features. Circulation 116: 1569-1576, 2007. 3. George, C. H., Higgs, G. V., Lai, F. A. Ryanodine receptor mutations associated with stress-induced ventricular tachycardia mediate increased calcium release in stimulated cardiomyocytes. Circ. Res. 93: 531-540, 2003.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
  • Target

    RYR2 (Ryanodine Receptor 2 (Cardiac) (RYR2))

    Andere Bezeichnung

    RYR2

    Hintergrund

    Synonyms: B-lymphocyte antigen CD19, Differentiation antigen CD19, CD19, Cd19

    Background: Ryanodine receptor 2 (RYR2) is a protein found primarily in cardiac muscle. In humans, it is encoded by the RYR2 gene. This gene encodes a ryanodine receptor found in cardiac muscle sarcoplasmic reticulum. The encoded protein is one of the components of a calcium channel, composed of a tetramer of the ryanodine receptor proteins and a tetramer of FK506 binding protein 1B proteins, that supplies calcium to cardiac muscle. Mutations in this gene are associated with stress-induced polymorphic ventricular tachycardia and arrhythmogenic right ventricular dysplasia.

    Molekulargewicht

    564 kDa

    Gen-ID

    6262

    UniProt

    Q92736

    Pathways

    Myometrial Relaxation and Contraction
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