SKAP2 Antikörper (AA 124-208)

Produktnummer ABIN7599870

Der Kaninchen Polyklonal Anti-SKAP2-Antikörper wurde für WB, ELISA und FACS validiert. Er ist geeignet, SKAP2 in Proben von Human und Maus zu detektieren.

Kurzübersicht für SKAP2 Antikörper (AA 124-208) (ABIN7599870)

Target: SKAP2 (Src Kinase Associated Phosphoprotein 2 (SKAP2))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SKAP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Produktdetails anti-SKAP2 Antikörper

Bindungsspezifität: AA 124-208

Verwendungszweck: Anti-SKAP2 Antibody Picoband®

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-SKAP2 Antibody Picoband® (ABIN7599870). Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human SKAP2 recombinant protein (Position: E124-E208).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.25-0.5 μg/mL, Human, Mouse
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Kouroku, Y., Soyama, A., Fujita, E., Urase, K., Tsukahara, T., Momoi, T. RA70 is a src kinase-associated protein expressed ubiquitously. Biochem. Biophys. Res. Commun. 252: 738-742, 1998. 2. Liu, J., Kang, H., Raab, M., da Silva, A. J., Kraeft, S.-K., Rudd, C. E. FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells. Proc. Nat. Acad. Sci. 95: 8779-8784, 1998. 3. Marie-Cardine, A., Verhagen, A. M., Eckerskorn, C., Schraven, B. SKAP-HOM, a novel adaptor protein homologous to the FYN-associated protein SKAP55. FEBS Lett. 435: 55-60, 1998.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Details zu SKAP2

Target: SKAP2 (Src Kinase Associated Phosphoprotein 2 (SKAP2))

Andere Bezeichnung: SKAP2

Hintergrund:

Synonyms: ELAV-like protein 2, ELAV-like neuronal protein 1, Hu-antigen B, HuB, Nervous system-specific RNA-binding protein Hel-N1, ELAVL2, HUB

Tissue Specificity: Brain, neural-specific.

Background: Src kinase-associated phosphoprotein 2 is an enzyme that in humans is encoded by the SKAP2 gene. The protein encoded by this gene shares homology with Src kinase-associated phosphoprotein 1, and is a substrate of Src family kinases. It is an adaptor protein that is thought to play an essential role in the Src signaling pathway, and in regulating proper activation of the immune system. This protein contains an amino terminal coiled-coil domain for self-dimerization, a plecskstrin homology (PH) domain required for interactions with lipids at the membrane, and a Src homology (SH3) domain at the carboxy terminus. Some reports indicate that this protein inhibits actin polymerization through interactions with actin assembly factors, and might negatively regulate the invasiveness of tumors by modulating actin assembly. Alternative splicing results in multiple transcript variants encoding different isoforms.

Molekulargewicht: 41 kDa

Gen-ID: 8935

UniProt: O75563