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LARP1 Antikörper (AA 123-401)

LARP1 Reaktivität: Human, Maus WB, ELISA, IF, IHC, ICC, FACS Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7599861
  • Target Alle LARP1 Antikörper anzeigen
    LARP1 (La Ribonucleoprotein Domain Family, Member 1 (LARP1))
    Bindungsspezifität
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 123-401
    Reaktivität
    • 17
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Maus
    Wirt
    • 15
    • 2
    Kaninchen
    Klonalität
    • 17
    Polyklonal
    Konjugat
    • 17
    Dieser LARP1 Antikörper ist unkonjugiert
    Applikation
    • 16
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS)
    Verwendungszweck
    Anti-LARP1 Antibody Picoband®
    Kreuzreaktivität (Details)
    No cross-reactivity with other proteins.
    Produktmerkmale
    Anti-LARP1 Antibody Picoband® (ABIN7599861). Tested in ELISA, IF, IHC, ICC, WB, Flow Cytometry applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
    Aufreinigung
    Immunogen affinity purified.
    Immunogen
    E.coli-derived human LARP1 recombinant protein (Position: K123-E401).
    Isotyp
    IgG
    Top Product
    Discover our top product LARP1 Primärantikörper
  • Applikationshinweise
    Western blot, 0.25-0.5 μg/mL, Human
    Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human, Mouse
    Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
    Flow Cytometry (Fixed), 1-3 μg /1x106 cells, Human
    ELISA, 0.1-0.5 μg/mL, -
    1. Chauvet, S., Maurel-Zaffran, C., Miassod, R., Jullien, N., Pradel, J., Aragnol, D. dlarp, a new candidate Hox target in Drosophila whose orthologue in mouse is expressed at sites of epithelium/mesenchymal interactions. Dev. Dyn. 218: 401-413, 2000. 2. Hartz, P. A. Personal Communication. Baltimore, Md. 5/16/2008. 3. Nagase, T., Ishikawa, K., Suyama, M., Kikuno, R., Miyajima, N., Tanaka, A., Kotani, H., Nomura, N., Ohara, O. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 5: 277-286, 1998.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Konzentration
    500 μg/mL
    Buffer
    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
  • Target
    LARP1 (La Ribonucleoprotein Domain Family, Member 1 (LARP1))
    Andere Bezeichnung
    LARP1 (LARP1 Produkte)
    Hintergrund

    Synonyms: Interferon regulatory factor 9,IRF-9,IFN-alpha-responsive transcription factor subunit,ISGF3 p48 subunit,Interferon-stimulated gene factor 3 gamma,ISGF-3 gamma,Transcriptional regulator ISGF3 subunit gamma,IRF9,ISGF3G,

    Tissue Specificity: Leukocytes.

    Background: La-related protein 1 (LARP1) is a 150 kDa protein that in humans is encoded by the LARP1 gene. La-related protein 1 (LARP1) is a ubiquitously expressed RNA binding protein that promotes both global and specific mRNA translation in cells. LARP1 belongs to the La-related protein family and contains two RNA binding domains, a La motif (LAM), and a neighboring RNA recognition motif-like (RRM-L) domain. Research studies indicate that LARP1 acts downstream of mTORC1 to facilitate cell proliferation and growth by promoting global mRNA translation and translation of mRNAs containing a 5'Terminal Oligo-Pyrimidine (5'TOP) motif, which code for translational machinery components. At the molecular level, LARP1 associates with 5'TOP mRNAs and multiple translation machinery components to positively regulate translation. Additional studies show that LARP1 expression is upregulated in hepatocellular carcinoma (HCC) patients and that high LARP1 expression in HCC negatively correlates with survival rate.

    Molekulargewicht
    150 kDa
    Gen-ID
    23367
    Pathways
    SARS-CoV-2 Protein Interaktom, Phosphorylierungen bei SARS-CoV-2 Infektion
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