PARP9 Antikörper (AA 117-824)

Produktnummer ABIN7599784

Produktdetails anti-PARP9 Antikörper

Target: PARP9 (Poly (ADP-Ribose) Polymerase Family, Member 9 (PARP9))

Bindungsspezifität: AA 117-824

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PARP9 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Verwendungszweck: Anti-PARP9 Antibody Picoband®

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-PARP9 Antibody Picoband® (ABIN7599784). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human PARP9 recombinant protein (Position: R117-E824).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.25-0.5 μg/mL, Mouse, Rat
ELISA, 0.1-0.5 μg/mL, -
1. Aguiar, R. C. T., Takeyama, K., He, C., Kreinbrink, K., Shipp, M. A. B-aggressive lymphoma family proteins have unique domains that modulate transcription and exhibit poly(ADP-ribose) polymerase activity. J. Biol. Chem. 280: 33756-33765, 2005. 2. Aguiar, R. C. T., Yakushijin, Y., Kharbanda, S., Salgia, R., Fletcher, J. A., Shipp, M. A. BAL is a novel risk-related gene in diffuse large B-cell lymphomas that enhances cellular migration. Blood 96: 4328-4334, 2000. 3. Juszczynski, P., Kutok, J. L., Li, C., Mitra, J., Aguiar, R. C. T. BAL1 and BBAP are regulated by a gamma interferon-responsive biional promoter and are overexpressed in diffuse large B-cell lymphomas with a prominent inflammatory infiltrate. Molec. Cell. Biol. 26: 5348-5359, 2006.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Details zu PARP9

Target: PARP9 (Poly (ADP-Ribose) Polymerase Family, Member 9 (PARP9))

Andere Bezeichnung: PARP9 (PARP9 Produkte)

Hintergrund:

Synonyms: PHD finger protein 21A; BHC80a; BRAF35-HDAC complex protein BHC80; PHF21A; BHC80; KIAA1696; BM-006

Tissue Specificity: Highly expressed in brain. Expressed at much lower level in other tissues.

Background: Poly (ADP-ribosyl)ation is a post-translational modification of proteins mediated by one of the 17 members of the poly (ADP-ribose) polymerases (PARP). PARP-9 belongs to the subfamily of macroPARPs, associating one to three macro domains to the PARP domain. Overexpression of PARP-9 stimulates cell migration in vitro, suggesting a role for PARP-9 in the promotion of malignant B cell migration and dissemination in high risk DLBCL. PARP-9 is also likely a transcription coactivator, its overexpression in B lymphocytes, stimulated by IFNγ, inducing the transcription of IFNγ-controlled genes.

Molekulargewicht: 96 kDa

Gen-ID: 83666