TWF1 Antikörper (AA 116-350)

Produktnummer ABIN7599771

Der Kaninchen Polyklonal Anti-TWF1-Antikörper wurde für WB, ELISA und FACS validiert. Er ist geeignet, TWF1 in Proben von Human zu detektieren.

Kurzübersicht für TWF1 Antikörper (AA 116-350) (ABIN7599771)

Target: TWF1 (Twinfilin, Actin-Binding Protein 1 (TWF1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TWF1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Produktdetails anti-TWF1 Antikörper

Bindungsspezifität: AA 116-350

Verwendungszweck: Anti-TWF1 Antibody Picoband®

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-TWF1 Antibody Picoband® (ABIN7599771). Tested in ELISA, WB, Flow Cytometry applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human TWF1 recombinant protein (Position: H116-D350).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.25-0.5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg /1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Beeler, J. F., LaRochelle, W. J., Chedid, M., Tronick, S. R., Aaronson, S. A. Prokaryotic expression cloning of a novel human tyrosine kinase. Molec. Cell. Biol. 14: 982-988, 1994. 2. Meacham, C. E., Ho, E. E., Dubrovsky, E., Gertler, F. B., Hemann, M. T. In vivo RNAi screening identifies regulators of actin dynamics as key determinants of lymphoma progression. Nature Genet. 41: 1133-1137, 2009. 3. Paavilainen, V. O., Hellman, M., Helfer, E., Bovellan, M., Annila, A., Carlier, M.-F., Permi, P., Lappalainen, P. Structural basis and evolutionary origin of actin filament capping by twinfilin. Proc. Nat. Acad. Sci. 104: 3113-3118, 2007.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Details zu TWF1

Target: TWF1 (Twinfilin, Actin-Binding Protein 1 (TWF1))

Andere Bezeichnung: TWF1

Hintergrund:

Synonyms: Aflatoxin B1 aldehyde reductase member 2, AFB1 aldehyde reductase 1, AFB1-AR 1, Aldoketoreductase 7, Succinic semialdehyde reductase, SSA reductase, AKR7A2, AFAR, AFAR1, AKR7

Tissue Specificity: Expressed in basement membranes of lung and kidney. Muscle- and neuron-specific isoforms are found. Isoforms (y+) with the 4 AA insert and (z+8) isoforms with the 8 AA insert are all neuron-specific. Isoforms (z+11) are found in both neuronal and non-neuronal tissues.

Background: Twinfilin-1 is a protein that in humans is encoded by the TWF1 gene. This gene encodes twinfilin, an actin monomer-binding protein conserved from yeast to mammals. Studies of the mouse counterpart suggest that this protein may be an actin monomer-binding protein, and its localization to cortical G-actin-rich structures may be regulated by the small GTPase RAC1.

Molekulargewicht: 42 kDa

Gen-ID: 5756

UniProt: Q12792

Pathways: Regulation of Actin Filament Polymerization, Maintenance of Protein Location