Neurocan Antikörper (AA 1140-1179)

Produktnummer ABIN7599762

Dieses Anti-Neurocan-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Neurocan in WB und ELISA. Geeignet für Human, Ratte und Maus.

Kurzübersicht für Neurocan Antikörper (AA 1140-1179) (ABIN7599762)

Target: Neurocan (NCAN)

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Neurocan Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-Neurocan Antikörper

Bindungsspezifität: AA 1140-1179

Verwendungszweck: Anti-Neurocan/NCAN Antibody Picoband®

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-Neurocan/NCAN Antibody Picoband® (ABIN7599762). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human Neurocan/NCAN recombinant protein (Position: H1140-A1179).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.25-0.5 μg/mL, Mouse, Rat
ELISA, 0.1-0.5 μg/mL, -
1. Miró X, Meier S, Dreisow ML, Frank J, Strohmaier J, Breuer R, Schmäl C, Albayram 79, Pardo-Olmedilla MT, Mühleisen TW, Degenhardt FA, Mattheisen M, Reinhard I, Bilkei-Gorzo A, Cichon S, Seidenbecher C, Rietschel M, Nöthen MM, Zimmer A (September 2012). "Studies in humans and mice implicate neurocan in the etiology of mania". Am J Psychiatry. 169 (9): 982-90. 2. Rauch U, Karthikeyan L, Maurel P, Margolis RU, Margolis RK (Oct 1992). "Cloning and primary structure of neurocan, a developmentally regulated, aggregating chondroitin sulfate proteoglycan of brain". J Biol Chem. 267 (27): 19536-47.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Details zu Neurocan

Target: Neurocan (NCAN)

Andere Bezeichnung: NCAN

Hintergrund:

Synonyms: Neurocan core protein, Chondroitin sulfate proteoglycan 3, NCAN, CSPG3, NEUR,

Tissue Specificity: Brain.

Background: Neurocan core protein is a protein that in humans is encoded by the NCAN gene. Neurocan is a member of the lectican / chondroitin sulfate proteoglycan protein families and consists of neurocan core protein and chondroitin sulfate. It is thought to be involved in the modulation of cell adhesion and migration. In the human subjects, it was found that NCAN genotype was strongly associated with manic symptoms but not with depressive symptoms. In the mice, the absence of functional Neurocan resulted in a variety of manic-like behaviors, which could be normalized by administering lithium.

Molekulargewicht: 142 kDa

Gen-ID: 1463

UniProt: O14594

Pathways: Glycosaminoglycan Metabolic Process