Chloride Channel 5 Antikörper (AA 100-756)

Produktnummer ABIN7599619

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Chloride Channel 5 in WB und ELISA. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für Chloride Channel 5 Antikörper (AA 100-756) (ABIN7599619)

Target: Chloride Channel 5 (CLCN5)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Chloride Channel 5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-Chloride Channel 5 Antikörper

Bindungsspezifität: AA 100-756

Verwendungszweck: Anti-ClC-5/CLCN5 Antibody Picoband®

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-ClC-5/CLCN5 Antibody Picoband® (ABIN7599619). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human CLCN5 recombinant protein (Position: R100-S756).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.25-0.5 μg/mL, Mouse, Rat
ELISA, 0.1-0.5 μg/mL, -
1. Akuta, N., Lloyd, S. E., Igarashi, T., Shiraga, H., Matsuyama, T., Yokoro, S., Cox, J. P. D., Thakker, R. V. Mutations of CLCN5 in Japanese children with idiopathic low molecular weight proteinuria, hypercalciuria and nephrocalcinosis. Kidney Int. 52: 911-916, 1997. 2. Alex, P., Ye, M., Zachos, N. C., Sipes, J., Nguyen, T., Suhodrev, M., Gonzales, L., Arora, Z., Zhang, T., Centola, M., Guggino, S. E., Li, X. Clcn5 knockout mice exhibit novel immunomodulatory effects and are more susceptible to dextran sulfate sodium-induced colitis. J. Immun. 184: 3988-3996, 2010. 3. Blair, H. J., Ho, M., Monaco, A. P., Fisher, S., Craig, I. W., Boyd, Y. High-resolution comparative mapping of the proximal region of the mouse X chromosome. Genomics 28: 305-310, 1995.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Details zu Chloride Channel 5

Target: Chloride Channel 5 (CLCN5)

Andere Bezeichnung: CLCN5

Hintergrund:

Synonyms: Macrophage mannose receptor 1, MMR, C-type lectin domain family 13 member D, C-type lectin domain family 13 member D-like, Human mannose receptor, hMR, Macrophage mannose receptor 1-like protein 1, CD206, MRC1, CLEC13D, CLEC13DL, MRC1L1

Tissue Specificity: Ubiquitous.

Background: The CLCN5 gene encodes the chloride channel Cl-/H+ exchanger ClC-5. This gene encodes a member of the ClC family of chloride ion channels and ion transporters. The encoded protein is primarily localized to endosomal membranes and may function to facilitate albumin uptake by the renal proximal tubule. Mutations in this gene have been found in Dent disease and renal tubular disorders complicated by nephrolithiasis. Alternatively spliced transcript variants have been found for this gene.

Molekulargewicht: 100 kDa

Gen-ID: 1184

UniProt: P51795