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RARS2 Antikörper (AA 1-560)

Dieses Anti-RARS2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von RARS2 in WB, ELISA und FACS. Geeignet für Human, Maus und Ratte.
Produktnummer ABIN7599480

Kurzübersicht für RARS2 Antikörper (AA 1-560) (ABIN7599480)

Target

Alle RARS2 Antikörper anzeigen
RARS2 (Arginyl-tRNA Synthetase 2, Mitochondrial (RARS2))

Reaktivität

Human, Maus, Ratte

Wirt

  • 13
  • 2
Kaninchen

Klonalität

  • 15
Polyklonal

Konjugat

  • 12
  • 1
  • 1
  • 1
Dieser RARS2 Antikörper ist unkonjugiert

Applikation

  • 10
  • 8
  • 8
  • 2
  • 2
  • 1
Western Blotting (WB), ELISA, Flow Cytometry (FACS)
  • Bindungsspezifität

    • 4
    • 4
    • 2
    • 2
    • 2
    AA 1-560

    Verwendungszweck

    Anti-RARS2 Antibody Picoband®

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins

    Produktmerkmale

    Anti-RARS2 Antibody Picoband® (ABIN7599480). Tested in WB, Flow Cytometry, ELISA applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    E.coli-derived human RARS2 recombinant protein (Position: M1-R560). Human RARS2 shares 86.1% amino acid (aa) sequence identity with mouse RARS2.

    Isotyp

    IgG
  • Applikationshinweise

    Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
    Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
    ELISA, 0.1-0.5 μg/mL
    1. Edvardson, S., Shaag, A., Kolesnikova, O., Gomori, J. M., Tarassov, I., Einbinder, T., Saada, E., Elpeleg, O. Deleterious mutation in the mitochondrial arginyl-transfer RNA synthetase gene is associated with pontocerebellar hypoplasia. Am. J. Hum. Genet. 81: 857-862, 2007. 2. Li, Z., Schonberg, R., Guidugli, L., Johnson, A. K., Arnovitz, S., Yang, S., Scafidi, J., Summar, M. L., Vezina, G., Das, S., Chapman, K., del Gaudio, D. A novel mutation in the promoter of RARS2 causes pontocerebellar hypoplasia in two siblings. J. Hum. Genet. 60: 363-369, 2015. 3. Rankin, J., Brown, R., Dobyns, W. B., Harington, J., Patel, J., Quinn, M., Brown, G. Pontocerebellar hypoplasia type 6: a British case with PEHO-like features. Am. J. Med. Genet. 152A: 2079-2084, 2010.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
  • Target

    RARS2 (Arginyl-tRNA Synthetase 2, Mitochondrial (RARS2))

    Andere Bezeichnung

    RARS2

    Hintergrund

    Synonyms: RARS2, RARSL, Probable arginine--tRNA ligase, mitochondrial, EC 6.1.1.19, Arginyl-tRNA synthetase, ArgRS

    Background: This nuclear gene encodes a protein that localizes to the mitochondria, where it catalyzes the transfer of L-arginine to its cognate tRNA, an important step in translation of mitochondrially-encoded proteins. Defects in this gene are a cause of pontocerebellar hypoplasia type 6 (PCH6). Alternative splicing results in multiple transcript variants.

    Molekulargewicht

    66 kDa

    Gen-ID

    57038

    UniProt

    Q5T160
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